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For patients with advanced nasopharyngeal carcinoma who failed platinum-based chemotherapy, nivolumab + gemcitabine showed good efficacy

 Last Update: 2022-09-09
 Source: Internet
 Author: User

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▎Clinical problems:

A phase II study from the journal Clin Cancer Res evaluated the efficacy and safety of nivolumab in combination with gemcitabine in patients with nasopharyngeal carcinoma who had failed prior platinum-based chemotherapy

▎Research proposal:

This study is a phase II, multicenter, open-label, single-arm study involving 36 patients

▎Main findings:

(1) The ORR was 36.

(2) The treatment-related adverse events of grade 3 and above were hypertension (2.

(3) In the multivariate analysis of chromatin-modifying gene mutations, tumor mutation burden (≥2.

(4) Immunophenotype analysis showed that tumors with a high proportion of immune rejection immunophenotype were significantly associated with poor PFS outcomes (HR, 4.

▎ Outlook:

For patients with advanced nasopharyngeal carcinoma who failed platinum-based chemotherapy, nivolumab combined with gemcitabine has good efficacy and is safe and tolerable
.

Reference: [1] https://aacrjournals.
org/clincancerres/article/doi/10.
1158/1078-0432.
CCR-22-1238/707906/A-Phase-II-Study-of-Nivolumab-plus-Gemcitabine-
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