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Since the introduction of trans-retinoic acid and arsenic trioxide, acute promyelocytic leukemia (APL, identified by the FAB collaborative group as acute myeloid leukemia M3 type, hence the name M3 leukemia) has become the most potential subtype
However, the disease is characterized by a high mortality rate early (10%-17%), mainly due to severe coagulation disorders
Diagnostic points for APL
1.
References:
Cheli E, Chevalier S, Kosmider O, Eveillard M, Chapuis N, Plesa A, Heiblig M, Andre L, Pouget J, Mossuz P, Theisen O, Alcazer V, Gugenheim D, Autexier N, Sujobert P.