Focus on lupus to explore how to predict disease onset in systemic lupus erythematosus

Every year on May 10th, World Lupus Day, and May is Lupus Awareness Month, 10x Genomics would like to share a research paper that uses single-cell gene expression analysis to study vaccine responses and certain types of lupus Common baseline gene expression signatures between episodes (

May is Lupus Awareness Month, campaigns designed to raise awareness and drive resear.

Lupus is an autoimmune disea.

Clinicians want to be able to predict who will develop lupus, how and when the disease will strike, so focusing on the immune response after vaccination may shed light on the immune response in autoimmune diseases such as lup.

Vaccine response and lupus flare-up predicted with the same baseline characteristics

In previous work, .

Drilling down to the cellular level: single-cell analysis reveals activated networks

In a previous NIH cohort study, the predictive 10 genes were associated with the frequency of a specific B-cell subset—they express CD20 and high levels of CD3 To determine exactly which subsets of cells expressed signature genes, they employed multi-omics cytometry to simultaneously analyze gene expression and 82 cell surface proteins in 53,201 single cells from healthy individuals with high and low responses to influenza vaccines in the NIH cohort individu.

Activation of these molecular circuits has been shown to be involved in the progression of SLE and other autoimmune diseases (5), and this study provides further support that increased activation in the non-ictal state may imply that plasmablast-related Disease activity is high.

Advancing biomarkers and therapies for lupus

The results of this study suggest that immune and disease responses in certain autoimmune diseases can be predicted based on a common set of baseline marker genes, and that the onset of SLE may involve specific cells that can serve as disease markers or therapeutic targe.

references:

Kotliarov Y, et .