Find the key to fighting the new crown from the immune system

before the advent of the effects of drugs and vaccines, as well as the new crown any way weaken the virus harm to humans?May 7 launch of the Forum for the Future "Understanding the future" science lectures, Wuhan Union Hospital, director of Institute of Infectious Disease and Immunity YANG Dong-liang said that Chinese and foreign scholars are studying immunomodulatory therapies aimed at curbing inflammation damage caused by the storm, reducing infection conversion to critically ill patientsmore than 80% of infected persons manifested as mild, 15% progressed to severe, life-threatening of which 5% - showed symptoms of the new crown virus differences are so great, sometimes astonishing: it really the same kind of disease?To answer this question, we must start from the interaction between the virus and the host immune system"We found that differences in immune function plays a very important role between patients with mild and severe cases." YANG Dong-liang said that "the interaction of viral and host immune system determines the viral infection outcome understanding this interaction will help us develop new drugs to control diseases or new treatment strategies, but also help prevent conversion to the patient in the treatment of severe stage"
in the death race the process, the inflammatory storm (or 'cytokine storm') to rescue the lives of patients new crown tremendous obstaclesStorminflammation typically involves more cytokinesInflammatory cytokines and key SARS crisis is different type I interferons, the new crown viral infection caused by inflammation of the storm, interleukin-6 plays a very important roleTypically, interleukin-6 may help the body resist viral infections, but the high levels of interleukin 6 can lead to thrombosis, myocardial dysfunction and vascular leakage, inhibiting pathological changes in cellular immunity"elevated interleukin 6 so often indicates a poor prognosis." YANG Dong-liang saidfar, the treatment of inflammation of the storm is no cureBut YANG Dong-liang also said that the medical community is highly concerned about the targeted treatment of these inflammatory mediatorsThere are scholars are trying to use immunomodulators such as interleukin-6 antagonists, to carry out the new combination therapy for patients with crowns strategy "domestic scholars for interleukin-6 antagonists have been a certain amount of clinical research, get some of the more promising results, the treatment portion of critically ill patients achieved good results But now Clinical Data It is still very limited, but also to further expand the sample size "
YANG Dong-liang team also found that the new crown viral infections can induce a variety of specific antibodies, antibodies to different types of patients may be quite different meaning Some high titers of neutralizing antibodies critically ill patient, but not well protect patients "Is there a pathogenic role further study crown new virus antibody has a protective effect in addition to the need." "the body's immune response is to 'double-edged sword', one can clear the virus, a aspects can also cause damage to the body of the patient "YANG Dong-liang said How to make this "double-edged sword", he is a scholar and doctor to discuss the problem (A Biovalley Bioon.com)