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Fifth edition of the WHO classification MDS and AML (Interpretation Update)

 Last Update: 2023-01-04
 Source: Internet
 Author: User

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1.
The name WHO-HAEM5 renamed myelodysplastic syndroms (MDS) as myelodysplastic neoplasms (MDN), the factors of the name change, one of which emphasizes that MDS is a tumor nature, The second is consistent
with the naming of myeloproliferative tumors (MPNs).
Given the phonetic and grammatical similarities between MDN and MPN, it is considered that the abbreviation MDS is superior to MDN while MDS
is still used.

2.
Pathological hematopoiesisPathological hematopoiesis, as an important indicator of MDS diagnosis rather than an important basis in classification rules, in WHO-HAEM5 canceled the WHO-HAEM4R
MDS classification rule by the percentage of blasts, ring sideroblasts and the number of pathological hematopoietic series 。 However, MDS with unilineage pathological hematopoiesis (MDS-SLD) and multilineage pathological hematopoiesis (MDS-MLD) in WHO-HAEM4R is classified in other official versions as two subtypes under MDS with low blasts (MDS-LB), respectively, called MDS with low blasts and single lineage dysplasia, MDS-LB-SLD) and MDS with low blasts and multilineage dysplasia (MDS-LB-MLD).

The inductive classification structure is shown in the figure
.

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