FGFR1 mutation associated with internal bleeding in low-level glioma spontaneous tumors

It is rare for low-grade gliomas (low-grade gliomas, LGG) to develop spontaneous tumor internal bleeding; Therefore, it is of clinical significance to study the risk factors of internal bleeding in LGG spontaneous tumorsYukitomo Ishi of Hokkaido University School of Medicine in Japan and others found a higher incidence of mutations in LGG intrafibromyl growth factor receptor 1 (Fibroblast Growth Factor 1, FGFR1) of spontaneous tumor internal bleedingThe findings were published online in J Neurosurg in February 2020study methodsthe authors retrospectively analyzed 66 patients under 30 years of age who were pathologically diagnosed as WHO I or WHO IIAll cases were genetically tested to determine whether BRAF V600E, FGFR1 N546/K656, IDH1R132, IDH2 R172 and KIAA1549-BRAF (K-B) fusion gene mutations occurred and recorded spontaneous intra-tumor bleedingof the 66 patients, 39 were WHO Class I gliomas and 27 were WHO Class II gliomasDuring the follow-up, 5 cases (7.6%) had spontaneous tumor internal hemorrhage, including 4 cases of acute intra-tumor hemorrhage and 1 case of late-onset tumor internal hemorrhageThe incidence of spontaneous tumor stoma in WHO Class I and WHO Class II glioma was 5.1% and 11.1%, respectivelyFour haemorrhagic tumors are located in the middle line, including the hypothalamus and thalamusthe authors analyzed the BRAF, FGFR1, and IDH1/2 genes in 66 patientsThe K-B fusion gene mutation was detected in 18 patients (27.3%), braF V600E mutation was detected in 14 patients (21.2%), and braF V600E mutation was most common in WHO Class I gliomasEight (12.1%) IDH1/2 mutations were detected in all WHO Class II gliomas and 4 (6.1%) detected FGFR1 mutationsSpontaneous tumor internal hemorrhage occurred in 55.6% of patients with K-B fusion gene mutations and in patients with 100% of FGFR1 mutationsNone of braF mutations, IDH mutations, and wild BRAF/FGFR1/IDH patients developed spontaneous tumor internal bleedingSingle-factor analysis showed that there was a significant correlation between FGFR1 mutation and tumor double-sided distribution and internal bleeding in spontaneous tumors In 19 patients with tumors in the bilateral neural pathways, hypothalamus and thalamus, The FGFR1 mutation was significantly associated with internal bleeding in spontaneous tumors (p 0.001) conclusions
the results of the study showed that the Mutation of FGFR1 was significantly associated with internal bleeding in patients with low-level gliomas under 30 years of age The specific mechanism is not clear, and further research is needed on the molecular mechanism of The Tumor Bleeding caused by the FGFR1 mutation.