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FDA updates approval of pemigatinib for the treatment of relapsed or refractory myeloid/lymphoid tumors with FGFR1 rearrangement

 Last Update: 2022-09-08
 Source: Internet
 Author: User

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Efficacy was assessed in the FIGHT-203 study (NCT03011372), a multicenter, open-label, single-arm trial that enrolled 28 patients with relapsed or refractory MLN with FGFR1 rearrangement

Efficacy was determined based on complete remission (CR) rates

The most common (≥20%) adverse reactions were hyperphosphatemia, nail toxicity, alopecia, stomatitis, diarrhea, dry eye, fatigue, rash, abdominal pain, anemia, constipation, dry mouth, epistaxis, serous retinal detachment , Pain in extremities, loss of appetite, dry skin, indigestion, back pain, nausea, blurred vision, peripheral edema, and dizziness

The recommended dose of pemitinib is 13.

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