-
Categories
-
Pharmaceutical Intermediates
-
Active Pharmaceutical Ingredients
-
Food Additives
- Industrial Coatings
- Agrochemicals
- Dyes and Pigments
- Surfactant
- Flavors and Fragrances
- Chemical Reagents
- Catalyst and Auxiliary
- Natural Products
- Inorganic Chemistry
-
Organic Chemistry
-
Biochemical Engineering
- Analytical Chemistry
-
Cosmetic Ingredient
- Water Treatment Chemical
-
Pharmaceutical Intermediates
Promotion
ECHEMI Mall
Wholesale
Weekly Price
Exhibition
News
-
Trade Service
RNA has a variety of important physiological functions and can play a role in processes such as genetic coding, gene expression, gene regulation, and enzyme catalysis
Flaviviruses including dengue virus, Zika virus and West Nile virus can cause infection in the population and cause a series of potentially serious diseases
On November 5, 2021, Fang Xianyang, School of Life Sciences, Tsinghua University, and Chen Chunlai’s research group jointly published an online publication titled "Pseudoknot Length Regulation of Flavivirus xrRNA Folding, Conformational Dynamics and Antibiotics" in Nature Communications.
smFRET technology is an important method to study the conformational dynamics of biological macromolecules.
Figure 1.
Next, the researchers integrated small-angle X-ray scattering (SAXS), smFRET, and anti-Xrn1 digestion kinetics experimental technology to study the folding of 11 xrRNAs of different lengths (2-7 bp) of PK2 from the flavivirus family in solution , Conformation dynamics and anti-Xrn1 enzyme cleavage activity (Figure 1d-f)
Figure 2.
Researcher Fang Xianyang and Researcher Chen Chunlai of School of Life Sciences of Tsinghua University are the co-corresponding authors of this paper
Original link: https://doi.
Links to related papers:
https://doi.
https://doi.
https://doi.
https://doi.
https://doi.
