Extract quercetin can fight cancer how is it 3 kinds of carcinogen again?

Quercetin, also known as quercetin, is insoluble in water and bitter because of its yellow alkaline aqueous solution Quercetin is widely found in nature Its English name "quercetin" reveals that quercetin originated from oak tree (English Name: quercetum) Quercetin is rich in tea, apple, onion, tomato, broccoli and other foods Quercetin plays an important role in the growth and development of plants Quercetin is a aglycone (component) of many other flavonoid glycosides For example, quercetin combines with rhamnose to form quercetin, rutin with rutinose, guava glucoside with arabinose, Hyperoside with lactose, etc Quercetin is generally used as a health product, often used to increase immunity or prevent infection Quercetin has a variety of effects, with better expectorant and antitussive effects, and has a certain antiasthmatic effect, used in the treatment of chronic bronchitis In addition, it can also reduce blood pressure, enhance capillary resistance, reduce capillary brittleness, reduce blood lipid, expand coronary artery, increase coronary blood flow, etc it also has auxiliary treatment effect on coronary heart disease and hypertension patients Our daily intake of vegetables and fruits is rich in biological flavonoids, most of which are quercetin, which shows the importance of these compounds in human diet In the aspect of anticancer, quercetin has been shown to inhibit various cancer cells In terms of specific mechanism, quercetin has a variety of biological effects, inhibiting the participation of various enzymes in cancer cells in cell proliferation and signal transduction pathway Low dose quercetin can inhibit the specific proliferation of cancer cells, which is caused by G1 cell cycle arrest Quercetin induced p21 CDK inhibitor accompanied with decreased phosphorylation of PRB, which inhibited G1 / s cell cycle by capturing E2F1 Low dose quercetin induced mild DNA damage and CHK2 activation, which are the main regulatory factors of quercetin on p21 expression In addition, quercetin downregulates cyclin B1 and CDK1, which are important components of G2 / M cell cycle The recruitment of NF-Y, a key transcription factor in quercetin inhibition, into the promoter of cyclin B1 gene leads to transcription inhibition This study shows that quercetin can achieve the chemopreventive effect of physiological related doses by inhibiting cell cycle progression On the other hand, there are also studies that show that quercetin has a certain synergistic effect and a certain application prospect when used in combination with commonly used chemotherapy agents or radiotherapy For example, quercetin can act on chemosensitization and radiosensitization chemotherapy as well as anti radiation, protecting normal cells from the side effects of chemotherapy and radiotherapy, which can significantly enhance its anti-cancer therapeutic effect However, quercetin, a quercetin extract from quercetin oak tree, was included in the list of three carcinogens released by the World Health Organization International Agency for cancer research last October In fact, the meaning of three kinds of carcinogens is different from that we usually understand Category 3 carcinogens refer to the fact that the existing evidence can not confirm the carcinogenicity of human beings, that is, the carcinogenicity evidence is insufficient For example, tea, caffeine, saccharin and its salts, diazepam, iron oxide, organic lead compounds, electrostatic magnetic field, melamine, mercury and its inorganic compounds are all three kinds of carcinogens The accurate definition of three kinds of carcinogens should be the compounds that have not yet been determined whether they have carcinogenic potential Therefore, although quercetin is listed in the list of 3 carcinogens, it is uncertain whether it has carcinogenic potential Quercetin has many functions, such as anti-oxidation, scavenging free radicals, inhibiting lipid peroxidation and so on It can resist oxidation, protect cardiovascular health, and show a good effect in anti-cancer However, the data of this kind of research are all from cytology experiments or animal experiments, and whether it works directly in human remains to be verified Quercetin health products are not recommended by the author, because it is different from other health products, quercetin and its analogues can be sufficient intake through fruits and vegetables.