Explore the stem cell treatment of systemic lupus erythematosus

Systemic lupus erythematosus (SLE) is a multi-organ involvement, multiple system self- immune diseases
.

Patients need to take glucocorticoids and immunosuppressive drugs for a long time to control their condition, but there are toxic side effects

Systemic lupus erythematosus (SLE) is a multi-organ involvement, multiple system self- immune diseases

Hematopoietic stem cell transplantation uses high-dose immunosuppressants or systemic radiotherapy to eliminate mature lymphocytes, reduce the number of autoantibodies and immune complexes, and induce immune tolerance through new hematopoietic stem cells to regenerate T and B lymphocytes, and ultimately make the body In the process of immune reconstitution, a new immune balance is achieved, and it is theoretically possible to achieve the goal of curing autoimmune diseases
.

Hematopoietic stem cells Hematopoietic stem cell transplantation, high-dose total body irradiation or an immunosuppressive agent clears itself mature lymphocytes, the number of autoantibodies and immune complexes is reduced by the new high-dose total body irradiation or transplant immunosuppressant clears itself mature lymphocytes , so reducing the number of self-antibodies and immune complexes, and through the new hematopoietic stem cells, hematopoietic stem cells regeneration T and B lymphocytes and induction of immune tolerance, the body eventually reach a new equilibrium in the immunization process of immune reconstitution, there are theoretically It is possible to achieve the goal of curing autoimmune diseases
.

Regenerate T and B lymphocytes to induce immune tolerance, and ultimately enable the body to achieve a new immune balance in the process of immune reconstitution.

In the past 10 years, scientists have conducted a large number of animal experiments and clinical trials, which have shown that stem cells play a therapeutic role through tissue repair, fibrosis, immunosuppression and immune regulation, including regulating the release of inflammatory factors, inducing immune tolerance, and inhibiting T and B cells.

In many foreign countries have adopted quite a number of foreign adoption in hematopoietic stem cells, hematopoietic stem cell transplantation in the treatment of patients with refractory SLE reported

At present, domestic scholars have carried out a self-controlled study of single-center and multi-center stem cell transplantation treatment, and found that stem cell treatment of systemic lupus erythematosus has good efficacy and safety

A multi-center clinical study is more convincing.

That it also be sufficient to show: Stem cell transplantation is important for improving systemic lupus erythematosus! Suffice it to say: stem cell transplantation is of great significance for improving systemic lupus erythematosus!

The scientists concluded that mesenchymal stem cell stem cell transplantation has the following advantages in the treatment of systemic lupus erythematosus:

The scientists concluded that mesenchymal stem cell stem cell transplantation has the following advantages in the treatment of systemic lupus erythematosus: The scientists concluded that mesenchymal stem cell stem cell transplantation has the following advantages in the treatment of systemic lupus erythematosus:

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Stem cells have low immunogenicity, are not prone to rejection, and have a high transplant success rate
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Stem cells have low immunogenicity, are not prone to rejection, and have a high transplant success rate
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      It can be seen that stem cell transplantation can effectively improve the symptoms of patients with systemic lupus erythematosus and alleviate the condition

 

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