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Expert Opin Investig Drugs: Disease Improvement in Ankylosing Spondylitis Treated with TNF Inhibitors

 Last Update: 2022-04-18
 Source: Internet
 Author: User

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According to ASAS/EULAR recommendations, non-steroidal anti-inflammatory drugs (NSAIDs) are the first-line treatment for AS; however, some patients may not respond adequately and others require continuous use to avoid symptoms; considering potential NSAID-related risks and/or side effects, which are not always possible

Infliximab is a human/mouse (75% and 24%, respectively) IgG1K allotype-neutralizing monoclonal chimeric antibody with specificity and high affinity for human tumor necrosis factor-alpha

Etanercept is a dimeric fusion protein of human TNF receptor linked to the Fc portion of human IgG1 [31]

Source: Garcia-Montoya L, Emery P, Disease modification in ankylosing spondylitis with TNF inhibitors: spotlight on early phase clinical trials.

Garcia-Montoya L, Emery P, Disease modification in ankylosing spondylitis with TNF inhibitors: spotlight on early phase clinical trials.
Expert Opin Investig Drugs 2021 Nov;30(11)

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