European Radiology: The role of texture features of ADC maps in predicting response to chemoradiotherapy in invasive bladder cancer

Radical cystectomy is the standard of care for patients with muscle-invasive bladder cancer (MIBC)
.

However, this procedure carries a high risk of perioperative complications , which can affect the patient's quality of life due to the need for urinary diversion .

Radical cystectomy is the standard of care for patients with muscle-invasive bladder cancer (MIBC)

In current bladder cancer clinical practice, magnetic resonance imaging (MRI) has become an important imaging tool for locoregional staging and assessment of treatment response .
Diffusion-weighted imaging (DWI) of MRI is a functional imaging technique that shows the degree of diffusional motion of water molecules in tissues .
In bladder cancer, apparent diffusion coefficient (ADC) value, a quantitative measure of DWI signal, has been reported to correlate with Ki-67 labeling index; in addition, tumors with lower ADC values ​​responded better to CRT .
However, there is some overlap between patients who achieve a complete response (CR) and those who do not , thus limiting its ability to predict CRT sensitivity .

Recently, texture analysis (TA) has been widely used in the qualitative assessment of various malignancies
.

TA can extract objective texture features (TFs) from digital medical images, whose numerical values ​​can be used for clinical decision support, providing better diagnostic , prognostic, and predictive accuracy .
However, to our knowledge, no studies have assessed the ability of TA to predict CRT sensitivity in MIBC .

Recently, texture analysis (TA) has been widely used in the qualitative assessment of various malignancies

Recently, a study published in the journal European Radiology explored the role of TFs in the ADC map in predicting the CRT response of MIBC, providing a valuable reference for the accurate formulation of bladder cancer treatment plans and prognosis prediction .
 

This study reviewed 45 MIBC patients, each of whom underwent cystectomy after CRT

Twenty-three patients achieved a pathological complete response (pCR) to CRT

Fig.

Correlation matrix between eight texture features (TFs) after the first feature selection process .
The numerical values ​​in the panels represent the Spearman rank correlation coefficient between the two features .

Fig.
Correlation matrix between eight texture features (TFs) after the first feature selection process .
The numerical values ​​in the panels represent the Spearman rank correlation coefficient between the two features .
In the correlation analysis, we excluded TFs with high correlation, including the mean apparent diffusion coefficient (ADC), second quartile (Q2) ADC, gray level co-occurrence matrix (GLCM) similarity and difference, gray level Run Length Matrix (GLRLM) Short Run Emphasis (SRE) and Grayscale Zone Length Matrix (GLZLM) Zone Percentage (ZE) .
Therefore, the first quartile (Q1) ADC, GLCM correlation, and GLCM homogeneity remained the features of final selection .

This study is the first to demonstrate the value of ADC map TA in predicting MIBCCRT response .
TFs from ADC maps may improve prediction of CRT response and may serve as novel imaging biomarkers to optimize selection of eligible patients for induction of CRT .

Original source :

Original source :

Koichiro Kimura , Soichiro Yoshida , Junichi Tsuchiya , et al .

Usefulness of texture features of apparent diffusion coefficient maps in predicting chemoradiotherapy response in muscle-invasive bladder cancer .
DOI: 10.
1007/s00330-021-08110-6

Koichiro Kimura Soichiro Yoshida Junichi Tsuchiya ,et al Usefulness of texture features of apparent diffusion coefficient maps in predicting chemoradiotherapy response in muscle-invasive bladder cancer 10.
1007/s00330-021-08110-6 10.
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