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European Radiology: Pathology-Grade Analysis of MYCN Amplification in Neuroblastoma Using Apparent Diffusion Coefficient (ADC) Histogram Analysis!

 Last Update: 2022-09-06
 Source: Internet
 Author: User

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According to statistics, neuroblastoma is the most common extracranial solid tumor in children

Clinically, an open or percutaneous needle biopsy is usually required to determine the cytogenetics of neuroblastoma

Diffusion-weighted imaging quantifies the random motion of protons in the body

Recently, a study published in the journal European Radiology evaluated the role of whole-tumor apparent diffusion coefficient (ADC) histogram analysis in identifying MYCN amplification status in neuroblastoma for a noninvasive, accurate, and comprehensive preoperative assessment of neuroblastoma.

This study retrospectively evaluated the imaging records of 62 patients with neuroblastoma (median age: 15 months (interquartile range (IQR): 7-24 months); 38 women) who were Magnetic resonance imaging was performed at this institution prior to initiation of any treatment or biopsy

MYCN-amplified neuroblastomas had statistically significantly higher maximal ADCs and lower minimal ADCs compared to non-amplified neuroblastomas, and also exhibited higher maximal ADCs than non-amplified tumors.

The present study provides preliminary retrospective data on the role of ADC histogram parameters in predicting MYCN-amplification

Original source:

Adarsh Ghosh, Ensar Yekeler, Deepa Dalal, et al.

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