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Primary central nervous system lymphoma (PCNSL) is an aggressive non-Hodgkin lymphoma that affects the brain, spinal cord, pia mater, cerebrospinal fluid and intraocular structures, accounting for 2-3% of all brain malignancies worldwide .
Primary central nervous system lymphoma (PCNSL) is an aggressive non-Hodgkin lymphoma that affects the brain, spinal cord, pia mater, cerebrospinal fluid and intraocular structures, accounting for 2-3% of all brain malignancies worldwide .
At present, a variety of imaging methods have been developed to monitor the changes in tumor vascular function and structure after chemotherapy , including diffusion-weighted imaging, corresponding apparent diffusion coefficient (ADC) maps, and dynamic contrast enhanced magnetic resonance imaging (DCE-MRI).
Recently, a study published in the journal European Radiology evaluated the role of dynamic enhanced magnetic resonance imaging (DCE-MRI) in predicting the chemotherapy response and clinical prognosis of patients with primary central nervous system lymphoma (PCNSL), providing clinical information Pre-treatment imaging biomarkers for predicting the treatment effect of PCNSL patients.
From 2016 to 2019, 56 patients who participated in this prospective study underwent DCE-MRI at baseline and 30 days after treatment.
From 2016 to 2019, 56 patients who participated in this prospective study underwent DCE-MRI at baseline and 30 days after treatment.
TheK transand Ve of the non-response group were higher than those of the response group (p <0.
The figure uses Kaplan-Meieran to analyze the PFS of PCNSL patients.
The figure uses Kaplan-Meieran to analyze the PFS of PCNSL patients.
DCE-MRI is an advanced imaging method for predicting the biological effects of tumor treatment.
Original source: Original source:
Fan Fu,Xuefei Sun,Yingying Li,et al.
Fan Fu,Xuefei Sun,Yingying Li,et al.
Dynamic contrast-enhanced magnetic resonance imaging biomarkers predict chemotherapeutic responses and survival in primary central-nervous-system lymphoma.
DOI: org/10.
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1007/s00330-020-07296-5 Fan Fu,Xuefei Sun , Yingying of Li, et Al the Dynamic Contrast-Enhanced Magnetic Resonance Imaging biomarkers Predict chemotherapeutic Responses and Survival in Primary Central-Nervous-System lymphoma.
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