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Eur J Cancer: Efficacy and safety of adjuvant therapy for melanoma in clinical practice: clinical research and reality

 Last Update: 2021-11-02
 Source: Internet
 Author: User

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Since 2011, the treatment pattern of metastatic melanoma has undergone tremendous changes

During the study period, a total of 2199 patients were registered in the DMTR database

In the entire study population, the 12-month relapse-free survival rate was 70.

RFS

In AJCC-7 stage IIIA patients, the 12-month recurrence-free survival rate was 87.

Multivariate analysis of related factors

The one-year follow-up group included 367 patients who were followed up for at least 12 months or died within 12 months

224 patients (61.

The 12-month RFS rate of patients in the 1-year follow-up group was 69.

In summary, studies have shown that in daily practice, adjuvant anti-PD -1 treatment after resection of stage III/IV melanoma shows a slightly higher toxicity rate and more frequent premature discontinuation, but compared with clinical studies, RFS The rates are similar

Original source:

de Meza MM, Ismail RK, Rauwerdink D, et al.
Adjuvant treatment for melanoma in clinical practice-Trial versus reality.
Eur J Cancer.
2021 Sep 29:S0959-8049(21)00575-X.
doi: 10.
1016/j.
ejca .
2021.
08.
044.
Epub ahead of print.
PMID: 34600790.

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