Eur J Anaesthesiol: Norepinephrine prevention lumbar-hard joint anaesthetic caesarean section associated low blood pressure: random double-blind dose study

Background and objectivein the lumbar cesarean ecth, low blood pressure can be preferred to norepinephrine rather than benzene epinephrine due to reduced cardiac palpitationsSince the optimal dose of norepinephrine is not yet known, the purpose of this study is to explore the dose response to low blood pressure after a caesarean sectionmethodselect 99 cases of patients with a selected period of caesarean section from February 1 to August 5, excluding patients with ASA grade III or above, preeclampsia or hypertension, previous diabetes or gestational diabetes, BMI of 35 kg m-2, height of 150 cm or 175, with local anaesthetic contraindicationsImmediately after the cobweb subcavity injection bubbica 10 mg gg gg, the preventive infusion of norepinephrine 0, 0.04, 0.05, 0.06 or 0.07 kg-1min-1The effects of different doses on hemodynamics were compared by evaluating half of the effective dose of norepinephrine or 95% of the effective dose (ED50 or ED95) using probability analysisresults0, 0.04, 0.05, 0.06 and 0.07?g kg-1min-1 dose group had 70%, 47.4%, 40%, 20% and 15%, respectivelyApgar scores or umbilical artery pH were similar between the groupsED50 value is 0.029 (95% CI 0.008 to 0.042 ?g kg-1min-1min-1), ED80 value is 0.068 (95% CI 0.055 to 0.099?gkg-1min-1), ED95 value is 0.105 ?gkg-1min-1 (95% CI 0.082 to 0.172 ?gkg-1min-1min-1)concludedED50, ED80 and ED95 were 0.029, 0.068 and 0.105 ?g-1min-1, respectivelyAfter the cobweb subcavity injection of bubicain 10 mg combined with sufffentan5 g, the infusion of norepinephrine 0.07 sgkg-1min-1 may be the best dose to prevent low blood pressure after lumbar hemp