ESR, complement, important indicators of systemic lupus erythematosus activity!

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with multi-system damage.

In the SLE laboratory examination items, erythrocyte sedimentation rate and complement are two common indicators of SLE, and they are also two indicators that fluctuate

What clinical reference value do they have for SLE patients?

0 1 ESR

Almost all patients with lupus erythematosus have an increased erythrocyte sedimentation rate (ESR)

ESR is a non-specific indicator, and many factors affect ESR, such as red blood cell number, red blood cell shape, red blood cell aggregation state, levels of CRP, fibrinogen, immune complexes, macroglobulin, and visceral substantial damage

Increased ESR may be due to changes in serum protein or changes in red blood cells

Some patients with a long course of disease still have relatively fast erythrocyte sedimentation rate even in the stable phase

0 2 complement

Complement (complement, C) is essentially a protein present in serum and interstitial fluid, which is heat-labile and has enzymatic catalytic activity after activation, which can mediate a series of immune responses and inflammatory responses

When complement is activated and gradually degraded through conventional or alternative pathways, its content also decreases

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with multi-system damage.

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with multi-system damage.

In the SLE laboratory examination items, erythrocyte sedimentation rate and complement are two common indicators of SLE, and they are also two indicators that fluctuate

What clinical reference value do they have for SLE patients?

0 1 ESR 0 1 ESR

Almost all patients with lupus erythematosus have an increased erythrocyte sedimentation rate (ESR)

Almost all patients with lupus erythematosus have an increased erythrocyte sedimentation rate (ESR)

ESR is a non-specific indicator, and many factors affect ESR, such as red blood cell number, red blood cell shape, red blood cell aggregation state, levels of CRP, fibrinogen, immune complexes, macroglobulin, and visceral substantial damage

Increased ESR may be due to changes in serum protein or changes in red blood cells

0 2 complement

0 2 Complement 0 2 Complement Complement (complement, C) is essentially a protein present in serum and tissue fluid, which is heat-labile, has enzymatic catalytic activity after activation, and can mediate a series of immune responses and inflammatory responses

In addition to indicating SLE activity, low C4 may also be a manifestation of SLE susceptibility (C4 deficiency)
.
C4 is the second activated complement molecule in the classical pathway, and it also reflects the changes of SLE patients to a certain extent, and its level changes can be used as an important indicator of SLE disease activity
.
When complement is activated and gradually degraded through conventional or alternative pathways, its content also decreases
.
Studies have found that complement C3 can be depleted through both the classical pathway and the alternative pathway, while complement C4 is depleted by the classical pathway alone.
Therefore, the level of complement C3 decreases more significantly than that of complement C4 during disease activity and infection
.
According to the above explanation of erythrocyte sedimentation rate and complement examination in SLE patients, we can make it clear that C3 and C4 are sensitive specific indicators in the disease of SLE, but ESR can only be used as a reference indicator, and only by combining the two can a more accurate judgment be made Take appropriate treatment measures in a timely manner
.


leave a message here