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About half of patients with epilepsy who try to stop antiepileptic drugs (ASMs) experience a seizure recurrence
.
Dozens of potential risk factors are associated with seizure recurrence
About half of patients with epilepsy who try to stop antiepileptic drugs (ASMs) experience a seizure recurrence
Based on previous studies, Gong Qiyong's team from West China Hospital analyzed the FC of each thalamic subregion in patients with epilepsy recurrence after antiepileptic drug withdrawal
The study prospectively enrolled and followed up patients with chronic epilepsy who attempted drug withdrawal; 19 had no seizures (SF group), 18 had seizure recurrence (SR group), and 28 were healthy controls
.
Resting-state functional magnetic resonance imaging was performed before drug discontinuation
The study prospectively enrolled and followed up patients with chronic epilepsy who attempted drug withdrawal; 19 had no seizures (SF group), 18 had seizure recurrence (SR group), and 28 were healthy controls
The intra-group comparison showed that the SR group had more extensive functional connectivity than the SF group; the functional connectivity of the left suboccipital nucleus of the thalamus, the left thalamus medial occipital nucleus, the right preoccipital nucleus of the right thalamus and the precuneus was significantly stronger than that of the SF group.
Differences in functional connectivity between groups
Differences in functional connectivity between groupsCorrelation analysis between FC and clinical variables
Correlation analysis between FC and clinical variablesLeft-precuneus FC in the SR group was positively correlated with active period (r = 0.
67, p = 0.
002), seizure-free period (r = 0.
58, p = 0.
01) and disease duration (r = 0.
53, p = 0.
02) relation,
67, p = 0.
002), seizure-free period (r = 0.
58, p = 0.
01) and disease duration (r = 0.
53, p = 0.
02) Relationship between left-precuneus FC in SR group with active period (r = 0.
67, p = 0.
002), seizure-free period (r = 0.
58, p = 0.
01) and disease duration (r = 0.
53, p = 0.
02) is positively correlated,
The left thalamic medial occipital nucleus-precuneus FC was positively associated with seizure freedom (r = 0.
58, p = 0.
01)
.
58, p = 0.
01)
.
The left thalamic medial occipital nucleus-precuneus FC was positively associated with seizure freedom (r = 0.
The combination of these thalamocortical connections showed high predictive power with an AUC=0.
Patients with epilepsy relapse had more extensive and stronger thalamocortical FC in those who discontinued antiepileptic drugs than in those who did not
original source
original sourceTan G, Li X, Niu R, et al.
Tan G, Li X, Niu R, et al.
Functional connectivity of the thalamocortical circuit in patients with seizure relapse after antiseizure medication withdrawal.
Epilepsia .
2021;62(10):2463-2473.
doi:10.
1111/epi.
17014 Tan G , Li X, Niu R, et al.
Functional connectivity of the thalamocortical circuit in patients with seizure relapse after antiseizure medication withdrawal.
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