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newsRecently, BI scientist Darryl McConnell published an article in J Med Chem analyzing the interaction between biotin and avidin
Drug source analysis
Drug source analysisBiotin is a miraculous molecule, and its binding ability to avidin surpasses that of all known non-covalent small molecule ligands and any protein
A core task of drug design is to find a ligand that has sufficient binding power with the target protein
The classic molecular interactions in drug design mainly include hydrophobic interactions, ionic interactions, dipolar interactions, and hydrogen bonds, which also exist in the biotin/avidin complex
This analysis is only based on the observation of crystal structure and SAR analysis, but correlation does not equal cause and effect