Embixing cpi raw material research and development project anti-tumor experimental scientific research

Embicion Special Topic Nitrogen Mustard Hydrochloride Specification: Nitrogen Mustard is the earliest anti-tumor drug used in clinical practice and achieved outstanding efficacy, and is a representative of
dichloroethylamine alkylating agent.

Over the years, the external use of nitrogen chloride chloride in the treatment of leukoiodine wind has obtained a more significant effect, but its adverse reactions should also be paid attention to, mainly for the local irritation of the skin mucous membrane, and occasionally allergic reactions are also reported to be squamous cell carcinoma and cherry-like hemangiomas, nitrogen chloride mustard is a double function
.

Embixing, also known as nitrogen mustard, nitrogen chloride mustard, is one of the earliest drugs used in clinical tumors, can be used as a representative of other alkylating agents anti-tumor drugs, and its derivatives still occupy a certain position
in clinical treatment.

This class of drugs have active alkylating genes, which can act with the amino, mercapto, carboxyl and phosphoric acid of cells, affecting the metabolism of cells and leading to cell death
.

It is a non-specific drug
of the cell cycle.

After this product enters the human body, the chloride ion is explained in the body water, which becomes a free radical, and through the cyclization within the molecule, a highly active ethylene imide ion is formed, which can alkylate with deoxyribonucleic acid, affect nucleic acid metabolism, inhibit cell mitosis, and have a strong cytotoxic effect
.

The disadvantage is that the effect of tumor cells and normal cells is not much different, the selectivity is poor, so the toxicity is also large
.

After entering the body, Embixing dissociates quickly, and 90% of the drugs in the plasma disappear within 0.
5 to 1 minute, so the effect is short-lived
.

However, its effect can last for a long time
.

The distribution in the body is not obviously selective, but the distribution in the brain is less, and a very small amount is excreted
from the urine in its original form.

At present, Embizing has been clinically used in the treatment of malignant lymphoma in China, including Hodgkin's disease, lymphosarcoma, reticulocytic sarcoma, giant follicular lymphoma, funginoid disease and lung cancer, especially for undifferentiated cancer
.

If combined medications, the effect is better
.

It also has a certain effect
on chronic myeloid leukemia, chronic lymphocytic leukemia, breast cancer, ovarian cancer, chorioepithelial carcinoma, etc.

In addition, the treatment of head and neck cancer (such as nasopharyngeal cancer) with abdominal aortic blockade (hemibody blocking) and intravenous injection of large doses of nitrogen mustard has a good effect, which can protect part of the bone marrow and relatively increase the drug distribution of
the upper body.

Topical use of its ethanol or dimethyl sulfoxide (0.
05%) solution for the treatment of psoriasis and funginoid disease also has a good near-term effect
.

Malignant sumps can be given as intrapericardial injection.


Embizing can also be used as an immunosuppressant
.

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