Elimination of zearalenone pollution in large scale pig farms

As we all know: at present, the most direct harm of mycotoxin to pig farm is oestrogen excess caused by zearalenone! Environmental endocrine disruptors (EED) are exogenous chemicals that interfere with the normal endocrine function of animals and human body, mainly released from human activities to the environment, which can affect the normal hormone function of human body and animals With the development of industry and agriculture, the pollution of EED is more and more serious, which has attracted global attention Epidemiological investigation and laboratory research found that eed can destroy the normal endocrine system function, leading to premature, infertility, and hypospadias, cryptorchidism and other reproductive organ development abnormalities Zearalenone (Zea), also known as F-2 toxin, is a mycotoxin produced by Fusarium graminearum Fusarium mainly damages corn, oats and other crops Zea produced by Fusarium exists in corn and corn products Animals can contact Zea through contaminated food, which is continuously absorbed by gastrointestinal tract The circulation of liver and intestines can also prolong the retention time in vivo, and milk can also excrete a certain amount of Zea Zea has reproductive developmental toxicity and immunotoxicity in animal experiments The results show that exposure to Zea can lead to infertility, congenital heart disease and other developmental abnormalities, as well as breast cancer In the developing body, especially in the fetus and newborn, some protective barriers, metabolism, excretion and other physiological functions are not perfect, which are more susceptible to Zea Therefore, the reproductive disorders caused by Zea pollution are more prominent A large number of studies have shown that estrogen and eed can play a role through estrogen receptor dependent and independent pathways Eed can bind to and activate estrogen receptor, improve the transcription of target gene and produce estrogen like effect In order to explore the mechanism of Zea, Zheng Jicui et al (2007) intervened with the estrogen receptor antagonist ici182780: in the experiment, it was found that the proliferation of sk-n-sh cells induced by E2 and Zea was significantly inhibited after the addition of ici1827800, and the increase of cell proliferation activity was not found in 72 hours This phenomenon suggests that Zea plays a role through the estrogen receptor pathway in promoting the proliferation of sk-n-sh cells How to change the serious harm of environmental endocrine disruptors (estrogen analogues -- zearalenone) to pig production? Use "Se selective estrogen receptor modulators (SERMs)"! Western medicine: according to the mother nucleus structure of SERMs and the structural classification method of Miquel and other nonsteroidal estrogen antagonists, SERMs can be divided into three main types: (1) triphenyleth ylenes derivatives: represented by TAM; (2) benzo [b] The derivatives of thiophenes are Renault (RAL) and naphthalene (NAF) Chinese medicine: wild pueraria lobata and wild Wudu clinical trials confirm that estrogen and its western medicine analogues will have obvious toxic and side effects in long term application, especially increase the risk of breast cancer and endometrial cancer, and limit their use Therefore, it is an important research topic to find safe, effective and long-term drugs for this kind of patients Some phytoestrogens have selective estrogen receptor regulation function, similar to synthetic estrogens in anti postmenopausal osteoporosis, and long-term use without side effects of estrogen Important ingredient 1: Pueraria lobata extract, a selective estrogen receptor regulator, regulates the estrogen level in vivo in two ways Pueraria lobata root is a common Chinese medicine, which was first recorded in Shennong Materia Medica, and was listed as the middle grade It has the functions of cool nature, flat Qi, sweet taste, heat clearing, fire fighting, detoxification and so on Analysis of modern medical methods shows that Pueraria lobata root is rich in 13 isoflavones, including puerarin, puerarin xyloside, daidzein, etc The main effective components are puerarin isoflavones, including puerarin and daidzein, which have good auxiliary effect on female endocrine and reproductive system diseases The two-way regulation of Pueraria isoflavones has weak estrogen like activity, which has two-way regulation on the level of estrogen action in vivo, especially for the prevention and treatment of estrogen imbalance related diseases This characteristic is like a double-edged sword When the body is lack of estrogen, Pueraria isoflavone can play a role in simulating estrogen supplement However, it has no effect on the normal estrogen level in vivo; when the estrogen level in vivo is too high, Pueraria isoflavone will prevent the excessive estrogen effect on the target organs, so as to maintain the balance of the estrogen level Therefore, Pueraria lobata root can keep the organs protected by estrogen, such as reproductive system and cardiovascular system, in a stable state It should be emphasized that Pueraria lobata has no estrogen structure, so there is no side effect of estrogen With the development of science and technology, the active function of polysaccharide has been recognized As one of the polysaccharides, the research of yeast cell wall polysaccharide is also in-depth Yeast cell wall polysaccharide has many active functions, such as adsorption of pathogenic bacteria, enhancement of cell immunity, enhancement of macrophage activity, anti radiation, anti-virus and anti-cancer function The chemical components are similar to sandwiches - mannan in the outer layer and dextran in the inner layer Both of them are complex branched polymers, in which there is a layer of protein molecules; there are a small amount of lipids and chitin on the cell wall; Yeast Polysaccharides account for 40% of the dry weight of yeast cell wall.