Eliminate cancer cells in 30 minutes! Where is the domestic anticancer boron drug sacred?

On November 23, 2021, Chongqing Gaojin Biotechnology Co.
, Ltd.
(“Gaojin Bio”) announced that the company has successfully developed the first BPA boron drug (L -Boronophenylalanine, namely (L)-4-dihydroxyboronyl phenylalanine or boron phenylalanine, a boron-containing amino acid derivative), this boron drug can remove cancer cells within 30 minutes at the fastest The effect of curing cancer
.

(Source: Gaojin Bio's official website) Why is boron medicine sacred? BNCT (Boron Neutron Capture Therapy) is one of the most advanced cancer treatments in the world
.

In 1936, the idea was proposed by American scientist Locher
.

The principle is that when epithermal neutrons collide with boron (B) isotope 10B, a powerful nuclear reaction will occur, causing 10B to split into two high-energy ray particles, namely alpha particles and 7Li particles; and these high-energy particles have a very short range.
, about 10um, which is exactly the same as the diameter of tumor cells
.

The high energy released in the particles is enough to destroy the genetic material nucleic acid in the tumor cells, and finally achieve the effect of killing the tumor cells
.

 Schematic diagram of the nuclear physical phenomenon of BNCT (Source: Gaojin Bio’s official website) Based on the above nuclear physical phenomenon, the treatment process of BNCT is as follows: ① Design a boron-loaded drug that can be targeted into tumor cells and can be injected into tumor cells.
enriched to an effective concentration; ② Design a technical scheme that can be traced in vitro, which can grasp the tumor site reached by boron-loaded drugs in real time; ③ Use a neutron source that can generate epithermal neutron beams to irradiate the tumor site, neutrons After colliding with the boron entering the cancer cells, a strong "nuclear reaction" is generated, releasing a very lethal heavy ion ray.
The ray has a very short range and will only kill the cancer cells without damaging the surrounding tissue
.

 BNCT treatment process (Source: Gaojin Bio's official website) The "jewel in the crown" of cancer treatment is well-deserved.
The reason why BNCT is known as the "jewel in the crown" of cancer treatment is because of its numerous advantages, which can be summarized as follows: Points: ①High safety, no need for surgery, BNCT can "mark" cancer cells, accurately destroy the DNA of cancer cells, and cause minimal damage to surrounding cells and tissues; ②The course of treatment is short, only 1-2 times of irradiation; ③The curative effect is predictable, BNCT therapy can track the boron drugs in the body, so the effect of the treatment can be “predicted” through nuclear medicine examination, to see whether the boron drugs are absorbed by the cancer cells, and whether the cancer cells are “tracked”; ④ Wide indications , For aggressive, multiple, recurrent, radiation-resistant, inoperable, and inoperable cancers that are not suitable for radiotherapy, BNCT therapy can be tried; ⑤Can be combined with a variety of carrier agents, with great development potential; The problem of drug resistance to therapy and immunotherapy; ⑦ The cost of treatment is relatively low, and BNCT boron drugs can be affordable by most families
.

 Therefore, these characteristics of BNCT make it promising to be one of the most ideal tumor treatment methods, benefiting many cancer patients
.

 BNCT development status - industrialization is ready to go 1 Looking at the global frontier progress At present, Japan, Finland, the United States, China and other countries are mainly conducting research and clinical trials of BNCT
.

Among them, Japan has been in the leading position for many years
.

In early March 2020, the Japanese Ministry of Health, Labour and Welfare approved the clinical application of the world's first BNCT device
.

On March 25, 2020, the world's first boron drug, Steboronine, was officially developed, mainly for the treatment of unresectable locally advanced or recurrent head and neck tumors.
This is the first official clinical application of BNCT in the world, and it also pioneered the fight against malignant tumors in humans.
new era
.

On May 27, 2020, Japan announced that BNCT officially accepted patients, and the treatment cost was about 300,000 yuan
.

In June of the same year, BNCT was included in the scope of medical insurance and entered the homes of ordinary people
.

So far, two institutions in Japan have used BNCT to treat patients, one is at the Osaka Medical University-Kansai BNCT Center; the other is at the South Tohoku General Hospital BNCT Center
.

In addition, BNCT, the National Cancer Center of Japan, is currently conducting clinical trials for malignant melanoma and angiosarcoma
.

2 Looking forward to a rising star in China In August 2020, China's first self-developed BNCT accelerator experimental device was successfully developed, laying a technical foundation for the localization and industrialization of China's medical BNCT treatment device
.

At present, the BPA boron drug of Gaojin Biological code "GJB01" has completed the pilot test and is about to enter the production approval application stage
.

Cai Shaohui, deputy general manager and project leader of Gaojin Bio, said, "The overall indicators of 'GJB01' are exactly the same as those of Steboronine, which is marketed in Japan, and it is more cost-effective.
It is expected to be used in clinical practice in 2023, and it is expected to be the first to be marketed in China.
BNCT anti-cancer boron drug
.

” BNCT boron drug may be able to produce good curative effect at a lower cost of medication, and is expected to provide a better choice for many cancer patients
.

 Author|Guo Haijun Typesetting|Qiao WeijunEndReference: [1] http:// 30 minutes to clear cancer cells, the pilot test of domestic anti-cancer boron drug is successful, only 100,000 is required to be covered by medical insurance Precedent https://xw.
qq.
com/amphtml/20220125A0369G00[3] China's first anti-cancer boron drug has completed the pilot test and is expected to be used in clinical practice in 2023 https://baijiahao.
baidu.
com/s?id=1717353284992508201&wfr= spider&for=pc[4] Precision anti-cancer technology is released! The domestic BNCT anti-cancer boron drug is here, and it is expected to be available in 2023 https://baijiahao.
baidu.
com/s?id=1718634397449191617&wfr=spider&for=pc[5] China's first anti-cancer boron drug completes the pilot test, the fastest 30 Many specific cancers can be cured in minutes! https://page.
om.
qq.
com/page/OPExf9dE-ts1BTH4RXSeCaVA0[6] Japan's latest "cancer killer" BNCT has been approved! The treatment cost is 300,000! How is it different from proton therapy? https://med.
sina.
com/article_detail_103_2_88919.
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