Effect of lotus seed extract on acute renal ischemia-reperfusion injury in rats
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Last Update: 2014-11-19
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Source: Internet
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Author: User
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Recently, researchers from Dongyang Hospital of traditional Chinese medicine in Zhejiang Province published a paper to study the effect of lotus seed extract on acute renal ischemia-reperfusion injury in rats, and preliminarily explore its mechanism of action, so as to provide theoretical basis for clinical application in the future It is suggested that lotus seed extract has protective effect on acute renal ischemia-reperfusion injury, and its mechanism may be related to anti free radical injury, reducing lipid peroxidation and anti thrombosis This article was published in the 09 issue of Chinese Journal of Nephrology combined with western medicine in 2014 Thirty healthy male SD rats were randomly divided into three groups: sham operation group (sham group), ischemia-reperfusion injury group (Riri group), lotus seed extract group (Le group) After 24 hours of reperfusion, malondialdehyde (MDA), superoxide dismutase (SOD), serum creatinine (SCR), urea nitrogen (BUN), MDA content in renal tissue and glutathione peroxidase (GSH PX) activity were measured The pathological changes of renal tissue and renal tubule score were observed with naked eye and light microscope Compared with the renal ischemia-reperfusion group, the content of MDA, SCR and BUN in serum, the content of SOD in serum, the score of renal tubule, the content of MDA in renal tissue and the activity of GSHPx in the lotus seed extract group decreased significantly (P < 0.01).
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