Effect of LFK, a probiotic extract of Enterococcus, on serum IL-12 in mice with allergic rhinitis

Recently, researchers from the otolaryngology department of the First Affiliated Hospital of Nanjing Medical University published a paper, aiming at the oral administration of lysed enterococci faecalis FK-23 strain (lysed Enterococcus faecalis) through heat treatment and enzyme cleavage in allergic rhinitis (AR) mice model FK-23, LFK), to observe the effect of LFK on the level of serum IL-12, and to explore the antiallergic effect of LFK on experimental ar It is suggested that LFK, a probiotic extract of Enterococcus, has a certain regulatory effect on IL-12, which may be related to its antiallergic effect This paper was published in the 3rd issue of Journal of Otolaryngology and ophthalmology of Shandong University in 2014 75 BALB / c mice were randomly divided into positive control group, LFK intervention group and negative control group The model of AR was established by ova intraperitoneal injection and nasal stimulation The negative control group was injected intraperitoneally and nasal drip with normal saline instead of ova In the positive and negative control group, 0.5 ml of normal saline was used instead of LFK On the 22nd day, the serum level of IL-12 was detected by enzyme-linked immunosorbent assay (ELISA) The level of serum IL-12 in the positive control group was significantly lower than that in the negative control group (P < 0.001), and that in the LFK intervention group was significantly higher than that in the positive control group (P < 0.001), but it was still significantly lower than that in the negative control group (P < 0.001).