Effect of balsam pear extract on Na ~ +, K ~ + - ATPase activity in renal cortex of diabetic rats

Recently, researchers from pharmacology teaching and research section of Zhuhai Campus of Zunyi Medical College published papers to explore the protective effect of Momordica charantia extract (MCE) on diabetic nephropathy (DN) and the effect on Na + +, K + - ATPase activity of renal cortex The results showed that balsam pear extract had a certain protective effect on renal injury in DN rats, and could inhibit the increase of Na +, K + - ATPase activity in renal cortex of DN rats This article was published in the Journal of Zunyi Medical College, No 02, 2015 Streptozotocin (STZ) - induced diabetic rats were randomly divided into normal group, model group, low and high dose group of MCE prevention, and low and high dose group of MCE treatment 24 h urine protein content, serum creatinine, urea nitrogen concentration and Na +, K + - ATPase activity in renal cortex of rats were measured Compared with the normal group, the 24-h urine protein content, serum creatinine, urea nitrogen concentration and Na +, K + - at P enzyme activity of the model group were significantly increased (P < 0.05); compared with the model group, the 24-h urine protein content, serum creatinine, urea nitrogen concentration and Na +, K + - at P enzyme activity of the model group were significantly increased (P < 0.05) The amount of urine protein, the concentration of serum creatinine, urea nitrogen and the activity of Na +, K + - ATPase in renal cortex were significantly reduced (P < 0.05 or P < 0.01), and the pathological changes of glomerular structure fuzziness and the increase of cell number of rats in DN group were alleviated in different degrees in each administration group of MCE; compared with the treatment group at the same dose, the prevention group of MCE was 24 H-urine protein, serum creatinine, urea nitrogen concentration and Na +, K + - ATPase activity in renal cortex all decreased more significantly (P < 0.05), and the pathological changes were alleviated more significantly.