Effect of Astragalus membranaceus on nitric oxide production by lipopolysaccharide activated macrophages in mice
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Last Update: 2014-06-23
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Source: Internet
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Author: User
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Recently, researchers from Shanxi Provincial People's Hospital published a paper to study the effect of Astragalus membranaceus extract and Astragaloside on the production of nitric oxide (no) by lipopolysaccharide (LPS) - activated mouse macrophage raw 264.7 cells, and to determine the content of astragaloside in the extract Astragalus membranaceus has the effect of inhibiting no production by LPS activated mouse macrophages, astragaloside A is one of its effective components This article was published in the first issue of the World Journal of integrated traditional and Western medicine in 2014 The toxic effects of astragalus extract and astragaloside a on raw 264.7 cells were determined by atplitetm The content of nitrite (NO2 -) in the cell culture medium after LPS activation of raw 264.7 cells was determined by Griss method, which indirectly reflected no production Curcumin was the positive control The content of astragaloside in the extract was determined by HPLC Astragalus extract in 200-400 μ g · ml-1 and astragaloside a in 10-20 μ g · ml-1 showed significant inhibition of no production (P0.05).
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