Ebiomedicine: reducing the risk of Alzheimer's through diet

September 19, 2019 / BIOON / - will following a certain diet affect the intestinal microbiota (beneficial and harmful bacteria living in the gastrointestinal tract), so as to reduce the risk of Alzheimer's disease? Researchers at Wake Forest School of medicine say this is a reasonable possibility In a small study, the researchers analyzed several different gut microbiome signals - chemicals produced by bacteria The study participants had mild cognitive impairment (MCI), and the researchers found that these bacterial signals were associated with higher levels of Alzheimer's disease markers in the CSF Photo source: https://cn.bing.com through cross group diet intervention, the study also showed that the Mediterranean ketogenic diet changed the intestinal microflora and its metabolites, which was related to the reduction of Alzheimer's disease markers in the two groups The study was published in the latest issue of the Journal ebiomedicine "The relationship between gut microbiome and diet and neurodegenerative diseases has recently received considerable attention This study shows that Alzheimer's disease is associated with specific changes in gut bacteria, and that a ketogenic Mediterranean diet affects microorganisms in a way that may affect the development of Alzheimer's disease," said the study author, Dr hariom Yadav, of Wake Forest medical school The randomized, double-blind, single point study involved 17 elderly people, 11 with mild cognitive impairment and 6 with normal cognition The participants were randomly assigned to follow a low carbohydrate modified Mediterranean ketogenic diet or a low-fat, high carbohydrate diet for six weeks, then switched to another diet after a six week "washout period." Before and after each diet, intestinal microflora, fecal short chain fatty acids and markers of Alzheimer's disease, including amyloid protein and tau protein, were measured in CSF The limitations of the study include the size of the population, which also leads to a lack of diversity in gender, race and age "Our findings provide important information for future interventions and clinical studies," Yadav said Identifying the specific role of these gut microbiota in the development of Alzheimer's disease may lead to new nutrition and treatment options that will effectively fight the disease "Reference: ravender nagpal et al Modified Mediterranean ketogenic diet modules got microbiome and short chain pretty acids in association with Alzheimer's disease markers in subjects with mild coherent improvement Ebiomedicine Doi: https://doi.org/10.1016/j.ebiom.2019.08.032