Eat more red meat, heart disease risk increases!

A new study on dietary interventions published in the European Heart Journal found that diets with red meat as the primary source of protein significantly increased levels of tAMONG tamongin in the cycle compared to diets that are not source of white meat or non-meat protein. The study also showed that long-term intake of red meat increases the ability of gut bacteria to produce TMAO and reduces the efficiency of kidney excretion of TMAO. Red meat both enhances the production of TMAO and reduces the excretion of TMAO, thus inducing an increase in TMAO levels in the body, which is associated with atherosclerosis and heart disease complications.
TMAO is a by-product of intestinal bacteria in the digestive process, when we eat a large amount of red meat, milk, eggs, in the intestinal flora and body organs under the action of a large number of TMAO. Numerous studies have shown that There is a close relationship between TMAO and cardiovascular diseases such as heart disease and stroke.
the study recruited 113 participants who, in order (in random order) were provided with a complete meal plan, with red, white and non-meat (mainly vegetarian) as the main source of protein. These diets account for 25% of total daily calorie intake. All participants "washed" the diet between the two diet plans.
after a month-long red meat diet, the vast majority of participants had elevated TMAO levels in their blood and urine. On average, t-MAO levels in the blood increased about threefold during the red meat diet compared to the white or non-meat diet, and the TMAO levels of some participants increased even by 10 times. TMAO levels in urine also rose. However, after they stopped eating red meat, TMAO levels in blood and urine decreased in the following month.
the study also led to an unexpected finding that participants' long-term dietary choices affected kidney function by changing the effectiveness of the kidney discharge of TMAO. For example, when the red meat diet reduces TMAO emissions, it increases the excretion efficiency of carnitine and other carnitine-derived metabolites."As far as we know, this is the first study of how well the kidneys can change the efficiency of excreting different compounds based on an individual's diet (except salt and water)," said Dr.
Hazen. We know that lifestyle factors are critical to cardiovascular health, and these findings build on our previous research on the link between TMAO and heart disease. They provide further evidence of how dietary interventions can be an effective treatment strategy to reduce TMAO levels and subsequent risk of heart disease. In another study just published in journal Clinical Research,
, Dr Hazen and his team have identified a potential new target that can prevent cardiovascular disease by digging deep into gut microbial pathways to convert carnitine into TMAO.
researchers found that carnitine (a nutrient rich in red meat, functional drinks and supplements) is converted into TMAO by different gut bacteria in the gut through a two-step process. The team found that the first step was similar in people who ate meat and vegetarian. But in the second step, TMAO was significantly enhanced in people who ate meat. The researchers further found that daily carnitine supplementation can induce the production of TMAO, even for vegetarians who still eat a normal diet. Earlier this year, Dr. Hazen published a study showing how researchers could devise a potential new drug to prevent heart disease and clotting risk by blocking the microbial pathways of choline into TMAO.
Dr Hazen's team compared the effects of daily oral carnitine supplements on eating meat and vegetarians. In the initial case, vegetarians' ability to convert carnitine into TMAO is limited, and meat eaters can quickly generate TMAO. After a month of adding carnitine, both groups showed an increase in the ability to produce TMAO."It's important to note that vegetarians can hardly convert carnitine from their diet into TMAO," says Dr.
Hazen. The intake of carnitine induction, even in the form of capsule supplements, provides us with important ideas for new interventions to inhibit TMAO, which can help reduce the risk of cardiovascular disease. By discovering this new approach, we may be able to develop new treatments that can be blocked during the onset and development of cardiovascular disease.
References:
Zeneng Wang et al. Impact of the chronic chronic diet red meat, white meat, or non-meat on triamine n-oxide sm and renal opion in healthy men and women.
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