East China Sea pharmaceutical micro ecological new drug industrialization technology won the first prize of scientific and technological progress in Shandong Province

On the morning of January 22, 2015, the Shandong science and technology award conference was successfully concluded, and all awards were announced Qingdao Donghai Pharmaceutical Co., Ltd won the first prize of 2014 Shandong science and technology progress award with the achievement of "series of micro ecological new drug industrialization technology development and application" project Professor Cui Yunlong, the first person who completed the project, was invited to receive the award and became Shandong Province The only leader of a pharmaceutical enterprise among the first prize winners of the provincial science and technology award is really one of the highlights Immediately after the conference, I interviewed Professor Cui Yunlong about this award-winning project "Professor Cui, the achievement of this award-winning project presided over by you can stand out among many candidates and win the only pharmaceutical science and technology award For China's microecology industry, it must be a supreme honor award and the pride of the Chinese people, so please ask what is your secret of success?" Professor Cui in front of the camera smiled and faced my question, Mr Cui said: "the secret of success lies in the pursuit and persistence of dreams Our dreams are to create health and long life for the people all the time This award is the result of our persistence in dreams, the result of our Donghai innovation and research team's continuous hard work for more than ten years, the best affirmation given by the people to our efforts and efforts, and more importantly, with the country The government's strong support for the cause of benefiting people's health cannot be separated " Yes, Professor Cui, as the winner of the highest award of this science and technology progress award, always takes it as his duty to serve the country and people's health Since the 1980s, the abuse of antibiotics in China has led to the high incidence of irritable bowel syndrome, chronic diarrhea, ulcerative colitis and other diseases related to the imbalance of intestinal flora In the prevention and treatment of these diseases, microecological drugs should have played an important role However, due to the backward technology of microecological drugs at that time and the secondary infection of some strains in the hospital, it has led to Products need 2-8 ℃ low temperature storage and transportation, unstable quality, poor efficacy and safety, doctors and patients distrust, which seriously affects the clinical promotion and application After studying abroad in Japan and returning to China, Mr Cui led the returned innovation and research team to obtain two new strains from more than 2000 samples for 11 years since 1997 Through the key technology of fermentation process and preparation process, he made a breakthrough in the research and created the exclusive technology of high-yield spore fermentation of anaerobic bacteria, making the spore yield of Clostridium caseinate more than 90% The spore forming rate of facultative anaerobe was over 95%, which solved the technical bottleneck of strict anaerobe spore production; The unique technology of microencapsulated proprietary preparation has enabled the storage and transportation of strictly anaerobic microecological drugs at room temperature, with a validity period of up to two years, solved the technical bottleneck of the storage and transportation of strictly anaerobic microecological drugs at low temperature, ensured the quality stability and clinical efficacy of the drugs, successfully solved the problems existing in the market of microecological drugs at that time, developed the storage and transportation at room temperature, stable quality A series of new microecological drugs, Clostridium butyricum viable preparation and Bacillus coagulans viable tablet, with good efficacy and safety without side effects, have been successfully industrialized under the support of high-tech industrial development project of national development and Reform Commission Speaking of the achievements of the project - a series of new microecological drugs baole'an, changli'ning, atanin and shuangshu'bao, whose gold content is really amazing, Professor Cui told me that the series of microecological projects that he presided over and completed were supported by four 863 projects of the Ministry of science and technology of the people's Republic of China, demonstration projects of the national development and Reform Commission, and strong support from local governments and science and technology departments, and experienced After more than ten years of hard work, the Haichuang research team obtained 4 new drug certificates (three of which are exclusive new drugs and one of class II new drug certificates), presided over the formulation of 4 national drug standards, and obtained 9 invention patents, including 2 American invention patents; published 5 monographs and 2 Science and education films The results of this project have been industrialized and passed the national GMP certification According to the results appraisal organized by Shandong Provincial Science and Technology Department, the achievements of this project have filled in the domestic blank and reached the international leading level About the promotion and application of the project, I learned some specific data from Professor Cui At present, four new drugs, such as atenin and baole'an, have entered more than 2000 secondary and above hospitals, with a total sales of more than 50 million boxes, benefiting more than 7 million patients Compared with traditional Chinese and Western medicine and antibiotics, atanin has a breakthrough effect on diarrhea type irritable bowel syndrome, ulcerative colitis and other persistent diseases It solves the problem that traditional medicine can only eliminate inflammation and sterilization, and can not eliminate the induced internal causes, but can not cure the symptoms and relapse easily It has won the praise and love of clinical experts and patients Among the millions of patients who have received effective treatment, there is a very special and ordinary patient whose feelings are worth sharing He is Academician Yuan Longping, the father of hybrid rice in the world Academician Yuan has suffered from diarrhea type irritable bowel syndrome for 27 years He has used a variety of Chinese and Western medicine and other microecological drugs and has not been cured He has diarrhea 4-6 times a day and suffered from it In 2006, after taking the project product atanin for two courses of cure, Yuan Lao was very happy and wrote "atanin - the lucky star of diarrhea patients" In 2010, Yuan Lao wrote "vigorously promote atenin to benefit patients with chronic diarrhea" again without recurrence after 4 years of recovery, expressing sincere trust and gratitude It has not recurred for eight years Academician Yuan, who has a high sense of social responsibility, experienced the good effect of microecological drug atenin on diarrhea type irritable bowel syndrome and learned that there are still a large number of patients in the society who can not receive effective treatment He was happily employed as a special scientific consultant to popularize the microecological drug atenin, and actively publicized it to his friends and patients It has played a good role in demonstration and promotion by spreading microecological knowledge and promoting atenin Professor Cui said that Mr Yuan's noble and simple behavior was moving, deeply infected and encouraged all members of the project team to continue to work hard to create more and better new drugs for the benefit of people's health He is an entrepreneur In order to realize the great dream of industry serving the country, President Cui resolutely gave up preferential treatment abroad, devoted all his talents and energy to the cause of benefiting national health, led a top scientific research team to devote themselves to the creation, research, achievement transformation and promotion of a series of micro ecological new drugs, and made great contributions to the country and national health; As a scholar, he has been devoting himself to the creation, research, industrialization and academic promotion of new microecological drugs for more than ten years, continuously improving the independent innovation ability of China's microecological drugs, making China's microecological products and technology research leading in China, leading in some aspects in the world, realizing the leapfrog development from strains to industrialization, and being a model of 863 scientific and technological achievements transformation in China, and being a domestic product There are 18 microecological drugs in total, 6 of which are initiated and researched by Chairman Cui Yunlong (including 2 national first-class new drugs and 1 national second-class new drugs), accounting for 1 / 3 of them This award is only 4 of them, and 6 national standards for microecological drugs have been formulated In 2014, the 5th microecology 863 project led by 7 domestic units is progressing smoothly; he is a dream chaser who has worked hard for 25 years only to eliminate pain, keep away from disease and achieve health and longevity for the general public; he is chairman Cui Yunlong and leader of Qingdao Donghai pharmaceutical industry