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DS-8201 is not the endpoint: the development of camptothecin and its derivative ADC and strategies to enhance therapeutic efficacy

 Last Update: 2022-09-09
 Source: Internet
 Author: User

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Over the past 20 years, topoisomerase inhibitors have been widely used as anti-cancer drugs

DNA topoisomerases are key enzymes for stabilizing DNA hyperpixes and resolving tangles, and are essential

TOP1 inhibitors have been studied extensively, several of which have been approved by

Although the efficacy of TOP1-ADC's TOP1 inhibitors in the treatment of cancer has been greatly improved, there is still a lot of room for improvement in the therapeutic effect of TOP1-ADC (Table 3

DNA damage regulator

PARP can promote DNA stabilization and repair

Top1 inhibitors have shown considerable potential as anti-tumor therapeutics; However, their poor pharmacokinetics and extra-target toxicity hinder their clinical application

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