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Drug target mechanism for various diseases including COVID-19

 Last Update: 2021-10-10
 Source: Internet
 Author: User

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McGill University professor Stéphane Laporte and other international research teams have discovered the working mechanism of potential drug targets for the treatment of cancer, rheumatoid arthritis, COVID-19 and other diseases
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The findings published in the journal Molecular Cell reveal the internal workings of cell receptors involved in cancer progression and inflammatory diseases

The defensin system is an integral part of our body's defense mechanism against pathogenic attacks including viruses
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When bacteria or viruses enter our body, the defensin system is activated, including two different membrane receptors C5aR1 and C5aR2

Arun Shukla of the Indian Institute of Technology (leader of this study) said: “Although the activation of the complement system is essential to combat harmful pathogens, excessive and continuous activation can lead to inflammation and even life-threatening, such as severe COVID-19.
Symptoms of complications
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The use of cutting-edge technologies such as CRISPR and cryo-electron microscopy has unlocked the internal working principle of C5aR2 and provided new opportunities for the therapeutic targeting of the new coronavirus
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"In order to treat COVID-19, some scientists are already trying to prevent the activation of the C5aR1 receptor, and clinical trials of Avdoralimab in patients with severe pneumonia caused by COVID-19 are already underway

Human cells are surrounded by receptors, which are important targets for drugs to produce beneficial effects
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The researchers explained that these receptors act as messengers because they receive and transmit signals that allow cells to trigger physiological processes in our body

"We are very excited to use cutting-edge technology to decipher the finer details of these receptors
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This information should enhance our basic knowledge about cell signaling and enable us to translate our findings into new drug discoveries," Arun Shukla concluded

Molecular Cell

DOI

10.

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