Drug combination therapy is expected to slow the HIV rebound

existing "antiretroviral therapy" can not cure AIDS, because HIV (HIV) will be "hidden" in the cell 'virus library'. U.S. researchers have found that a combination of the two drugs is expected to slow the virus's rebound after antiretroviral therapy stops.
a new study published in the British journal
suggests that linking HIV-targeted antibodies to innate immune system stimulators can slow or improve virus rebound in macaques.
researchers infected 44 macaques with SHIV, a virus that combines part of the "SIV" (monkey immunodeficiency virus) and "HIV" (human HIV) genome, and began 130 weeks of antiretroviral therapy a week after infection.
130 weeks of treatment, the researchers divided macaques into four groups on average. The first group was the control group, which did not receive other treatment, the second group and the third group increased the "extensively mediated antibody" and immunostululant therapy after 96 weeks, respectively, and the fourth group added two drugs after 96 weeks.
monitoring results after treatment showed that all control group macaques showed a virus rebound, the virus load peaked, almost all macaques treated with immunostigation agents showed a virus rebound, while macaques treated with "extensively medium antibodies" rebounded. There was a slight delay; of the 11 macaques treated with the drug, five did not have a virus rebound within six months of the end of antiretroviral therapy, while six macaques with a viral rebound had a much lower peak viral load than the control group.Dan Barush, co-author of the
paper and director of the Center for Virology and Vaccines at Beth Isrel Deacon Medical Center in the United States, said the combination of the two drugs maximizes the killing of HIV-infected cells and provides preliminary theoretical validation for potential therapeutic strategies for developing targeted virus libraries. (Source: Xinhua News Agency Zhou Zhou)