"Drinking tea" controls blood sugar stability

The team of Ye Haifeng, a researcher at the School of Life Sciences of East China Normal University, successfully developed a gene expression control system regulated by the green tea metabolite primary catechic acid (PCA) and applied the system to controlled oscic genetic remodeling, gene editing, biocomputer and precision drug delivery to treat diabetes. On October 24, the results were published online as cover articles in Science-Translational Medicine.
cell therapy is seen as the next generation of therapy, while artificial custom cell therapy is considered the backbone of the next generation of cell therapy. However, the lack of safe and efficient control devices is a major obstacle to the conversion of artificially customized cell therapies into clinical applications. This study takes the convenient way of "drinking tea" as a control method to intervene in time and space or regulate the controlled expression release of therapeutic drugs, which provides a new idea and strategy for the transformation of artificial customized cell therapy into clinical application.
Ye Haifeng told china Science Daily that in order to realize the concept of "tea-drinking regulation", the researchers used the green tea secondary metabolite proto-tea acid as a molecular switch to rationally design, assemble and reprogram biomolecule components from a transcriptional anti-blocking protein in a streptomycin response to proto-tea acid, and constructed a gene expression control switch for the regulation of raw tea acid. The original cateconic acid can accurately induce the expression of GM, and the control system shows good time, dose dependence and reversibleness in regulating GM expression.
now, researchers have applied the technique to studies such as the construction of an obitural genetic remodeling and gene-editing device for the regulation of primary acetic acid, and the design of a biocomputer for the regulation of food phenolic acid (primary acetic acid and vanilla acid). What's more, the primary acetic acid control switch can be used to control the expression of the blood sugar-lowering drug insulin/gluatic glucosin-like peptides, and the control system is applied to model mice and monkeys with type I. and type II diabetes, and has achieved long-term control of blood glucose stability.
ye Haifeng said the study was the first in the field of synthetic biology to implement logical computations in animals, laying the foundation for future complex and precise drug output and precision disease treatment. (Source: Huang Xin, China Science Journal)
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