Double agent of the immune system

A new study from Tel Aviv University (Tel Aviv University) tested the development of glioblastoma cancerous tumors in an animal model with a normal immune system for the first time, with the goal of best mimicking the development of human tumors

The research was led by Dr.

Glioblastoma is the most common type of brain cancer and one of the most violent and deadly cancers in humans; the average life span of a glioblastoma patient is 12 to 15 months from the moment of discovery

The research was conducted in Dr.

In this study, the researchers discovered that cells called neutrophils play a key role in the interaction with the growth of cancer cells

The researchers also found that neutrophils have been close to the tumor throughout the development of the tumor and continuously recruited from the bone marrow

Dr.

In addition, the researchers discovered that the process by which neutrophils change their properties can be carried out remotely, even before they develop into the tumor itself

"Studies have shown that changes in the nature of neutrophils occur in the bone marrow itself-without tumors: tumors are located only in the brain, and from there successfully change the cell characteristics of recruits," added Dr.

It is not difficult to imagine that these findings are the first step in deciphering the mechanism of interaction between the immune system and malignant tumors.

DOI

https://doi.

Article title

Exploring the longitudinal glioma microenvironment landscape uncovers reprogrammed pro-tumorigenic neutrophils in the bone marrow