Domestic anti AIDS drugs catch up

December 1 is the 27th World AIDS Day, and the theme of this year's event is still "get up and move towards zero aids - gather strength, overcome difficulties and control AIDS" Zero) is intended to show that China's AIDS prevention and control work has reached a critical period and is facing many difficulties and challenges It is necessary to mobilize governments, departments, social organizations and volunteers at all levels, concentrate all forces, emancipate the mind, open up innovation, solve problems in prevention and control work, and control the AIDS epidemic Recently, the National Center for Disease Control and prevention announced the epidemic situation in mainland China: as of August 31, 2014, 490521 cases of HIV / AIDS were reported alive and 149347 cases died; among the newly found cases, 64.6% were heterosexual transmission, 24.9% were same-sex transmission, 5.8% were injecting drug transmission, 0.9% were mother to child transmission, and other multi-channel transmission It can be seen from the data that the prevention and control of AIDS epidemic in China is quite arduous AIDS is a viral disease caused by HIV virus infection It was a newly identified disease in the early 80s of last century The largest AIDS area in the world is in sub Saharan Africa, followed by Southeast Asia and South America The incidence rate of Asian and American countries is not high According to WHO, the incidence rate of AIDS worldwide is growing rapidly every year, mainly due to the fact that AIDS in poor and underdeveloped countries has not been effectively controlled and is spreading rapidly According to the statistics of China's health sector, the total number of AIDS in China is nearly 500000 (there are still some AIDS patients who have not been diagnosed or treated, so the total number is about 1 million) According to a World Health Organization survey with huge market demand, in 2011, the total number of confirmed AIDS patients worldwide reached 34 million, with a mortality rate of 5% (much lower than people expected) The main reason is that since the 1980s, the western pharmaceutical powers led by the United States have increased the research and development of new anti HIV drugs According to reports, there are at least 90 kinds of new anti HIV drugs approved by the US FDA, and the annual sales volume of the International AIDS drug market has reached tens of billions of dollars In Europe and the United States, the anti HIV drug market is very active, and although China can produce more than ten kinds of anti HIV drugs, the export of products is very hot, but the domestic market has not been opened For this situation, some insiders believe that the incidence of AIDS is different from other viral diseases In the early stage, the disease has almost no symptoms, and does not affect the work and life of patients Until the later stage, because the HIV virus destroys the immune system of patients and makes them feel a variety of diseases, patients will take the initiative to go to the hospital for treatment In addition, due to the fear of public illness will be social discrimination, so domestic AIDS patients will not take the initiative to go to hospital Another reason for the low sales of anti HIV drugs in China is that the price of domestic anti HIV drugs is generally high (compared with India, Brazil and Thailand and other developing countries), which objectively results in the poor sales of domestic anti HIV drugs According to the estimation of relevant departments, the domestic market scale of anti HIV drugs is 2-3 billion yuan at present, which has a huge gap with the market of western countries In the 1990s, the domestic technology caught up with that of the last century, and Chinese enterprises imitated and produced the first anti HIV drug zidovudine Although the product was not much later than that in the west, due to the lack of scientific research funding for a long time, new drug research and development is a long way from developed countries It is reported that at present, there are dozens of anti HIV drug manufacturers in China, including more than 10 raw material drug manufacturers Northeast Pharmaceutical General Factory and Xiamen Mike pharmaceutical company are pioneers of domestic production of zidovudine At present, these two enterprises are also the largest exporters of zidovudine in China Subsequently, Shanghai deseno pharmaceutical company emerged as a new force and quickly became an important exporter of anti HIV drugs in China Due to the expiration of many patents for anti HIV drugs after the 1990s, it has opened the door for domestic production of anti HIV drugs that are popular in the international market However, China's production of anti HIV drugs started late, and many core technologies of products have not been mastered, so the majority of exports are old products, which has no obvious competitive advantage in the international market According to reports, at present, the total sales of anti HIV drugs of Squibb, Abbott, GlaxoSmithKline, MSD and other international pharmaceutical giants account for about 75% of the global anti HIV drug market, while the total sales of anti HIV drugs of other companies only account for less than 25% It can be seen that there is not a small gap between China's AIDS drugs and the advanced level of foreign countries It is gratifying that in recent years, Chinese pharmaceutical enterprises have increased the research and development of new anti HIV drugs If there are reports, anti HIV drugs with independent intellectual property rights in China have been put into production in succession, including de hydroxycreatinine developed in Shanghai and indenavir sulfate developed and produced in Zhejiang, so as to provide new means for clinical medicine to effectively deal with AIDS Recently, it was reported that Puxin company received letters from the World Health Organization and the US FDA respectively The key intermediates represented by zidovudine and lamivudine met relevant standards, and passed the on-site audit of who and FDA Puxin company is a national high-tech enterprise invested and built by Shanghai desino company, specializing in the production of intermediate and API of anti AIDS drugs The approval of who and FDA audit means that Puxin's products are qualified to be sold to developed countries such as the United States, and can also participate in the procurement bidding of World Health Organization and domestic medicine in the United States, which is considered to have obtained the "green pass" for entering North America and even the global pharmaceutical market Zidovudine is the first anti HIV drug API product that has been successfully imitated and exported to overseas market in China At present, the annual output in China is estimated at 16-18 tons, and the export volume is maintained at about 10 tons per year The main export markets of this product are India, Brazil, South Africa and Thailand In recent years, the market of this product in African countries has also opened At present, the three largest zidovudine manufacturers in China are Northeast Pharmaceutical General Factory, Xiamen Mike company and Shanghai deseno company In addition, the production of zidovudine in Henan Tianfang pharmaceutical industry has also increased rapidly in recent years Xiamen Mike company began to export zidovudine to the third world countries as early as more than ten years ago, and the export volume is increasing year by year It is also the second enterprise in China after Northeast Pharmaceutical General Factory In recent years, after these two enterprises, many more companies in China have joined in the export team of anti HIV drugs, including Shanghai desino company, Zhejiang Huahai pharmaceutical and other enterprises For example, in addition to some pharmaceutical and chemical plants in China, there are dozens of enterprises exporting anti HIV drugs According to the report of China Chamber of Commerce for the import and export of medicine and health care products, the quantity of zidovudine exported by China has been stable between 10-12 tons, while domestic sales only account for 1 / 3 For developed countries in Europe and the United States, zidovudine also exports a certain amount, but the quantity is not large It is understood that the export price set by zidov is about 210 US dollars / kg at present Stavudine, like zidovudine, is also a classic anti HIV drug in the international market, but it has a good market because of its exact effect According to reports, last year, the total global sales volume of stavus was 820 million US dollars The international medical community generally believed that stavus was a cost-effective anti AIDS drug It is understood that three companies in China have obtained the approval documents for the production of stavudine APIs, including Shanghai desino company, Meiji (Xiamen) pharmaceutical company and Wuhan Wujing pharmaceutical company Recently, it has been reported that three anti HIV APIs, stavudine, zidovudine and lamivudine, from Shanghai deseno Chemical Pharmaceutical Co., Ltd., have passed the new GMP certification At present, the annual output of domestic stavudine API is about 10-12 tons, and the export accounts for about 80-90% The proportion of domestic sales is very small It is understood that the current export price is 2600 yuan / kg Industry insiders believe that stavudine is a very popular anti HIV old product in the international market, so its export prospects are still good in the next few years In addition, there are several new anti HIV drugs with export advantages: in the past three years, the export volume of three new anti HIV drugs imitated and produced by Chinese manufacturers, nevirapine, fluranavir and ritonavir, has increased sharply, which has become a new highlight of the export growth of domestic anti HIV APIs According to the statistics of China Medical Insurance chamber of Commerce, in 2011, the total export value of nevirapine, fenvaleren and ritonavir made in China was 58 million US dollars In 2012, this figure has risen to 80 million US dollars, and last year, it increased to nearly 100 million US dollars It is expected that the total export value of these three new anti AIDS APIs will exceed 100 million US dollars, reaching 120 million to 150 million US dollars It is reported that the main producers and exporters of the three drugs are Zhejiang Huahai Pharmaceutical Co., Ltd., Shanghai desino Co., Ltd and Abbott (Hangzhou) Huadong Pharmaceutical Group, etc., and some other domestic pharmaceutical and chemical plants also have certain production It is estimated that the total domestic production of the three anti HIV APIs has exceeded 10 tons, and the export prospect of these products will continue to be promising in the next few years In conclusion, due to the huge number of AIDS patients in the world, and still growing, there is a huge demand for new and old anti HIV drugs in the international market However, due to various reasons, the domestic anti HIV drug market has always been in a "warm water" state, and the domestic anti HIV drugs show a "cold domestic and hot export" state With the implementation of the new medical insurance policy, it will promote the growth of the domestic market In the future, China's anti AIDS drug industry will show a trend of booming production and marketing More than ten thousand AIDS patients in Yunnan Province have been treated with traditional Chinese medicine, the Yunnan Institute of traditional Chinese medicine said recently that the province has treated more than ten thousand AIDS patients with traditional Chinese medicine in the past nine years Users significantly improved their quality of life and life cycle extension In 2004, the Ministry of finance, the health and Family Planning Commission and the State Administration of traditional Chinese medicine launched the pilot program of Chinese medicine for AIDS treatment, and the next year, Yunnan launched the work of Chinese medicine for AIDS treatment By the end of September 2014, 10814 patients in the province had been treated, and 5653 patients had been treated with traditional Chinese medicine, distributed in 12 prefectures and 43 treatment points The task assigned to Yunnan by the state is to reach 5000 cases after 2009, close to half of the number of tasks nationwide Yunnan Academy of traditional Chinese medicine is specifically responsible for the project of TCM treatment of AIDS in Yunnan Province Yunnan Province, located in the southwest of China, is one of the provinces with the largest number of HIV / AIDS patients According to the latest official statistics, since the first report of HIV infected people / patients in 1989, to October 2014, there were 79915 existing HIV infected people / patients in the province, and 9601 new reports from January to October 2014 "Of the more than 5600 patients now, 55% are treated with integrated traditional Chinese and Western medicine, and 45% are treated with pure traditional Chinese medicine The overall effect is good." He Lisheng said that at present, traditional Chinese medicine is mainly used in the treatment of AIDS in terms of antiviral drugs, directly using traditional Chinese medicine antiviral; in the infection period, improve the quality of life of patients The study found that the quality of life and