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A patient was prescribed omeprazole in the hospital because of gastric reflux
CA72-4 is a tumor marker for gastric cancer and many other cancers
What is CA72-4?
Clinically, the tumor marker CA72-4 is commonly used to distinguish gastric cancer, but patients with benign diseases and non-gastric cancer patients may also have elevated CA72-4 in some cases
The Roche Elecsys detection system manual mentions that CA72-4 has a sensitivity of 28%-80% for the diagnosis of gastric cancer and a specificity of more than 95% for the diagnosis of benign gastrointestinal diseases
Most tumor markers are broken down and excreted by the liver and kidneys
What if CA72-4 is elevated?
Is an elevated tumor marker cancer? Generally speaking, tumor markers are one of the indicators that assist in the diagnosis of tumors
An elevated tumor marker does not mean you have cancer
So, what if you really find that CA72-4 is elevated? The diagnosis of disease requires clinicians to collect the patient's medical history and symptoms, outpatient physical examination signs, and laboratory tests, which are all essential
If the patient's physical examination or occasionally finds that CA72-4 is elevated, especially low-level CA72-4 is elevated, there is no need to panic
If there is no other evidence to support it, and only low levels of CA72-4 are elevated, some related tests can be done.
Does taking stomach medicine increase the risk of stomach cancer?
Stomach medicine may be the main cause of CA72-4
Some studies have confirmed the link between omeprazole and the risk of gastric cancer
Therefore, although proton pump inhibitors are commonly used drugs for the treatment of gastric diseases and also help to reduce the risk of esophageal cancer in patients with Barrett's esophagus disease, side effects need to be considered for long-term use
A 2019 study in the Journal of Gastroenterology pointed out that long-term medication can cause vitamin B12 deficiency and iron deficiency anemia
All in all, the increase in CA72-4 after taking stomach medicine does not mean that you have stomach cancer
