Do lipid-lowering drugs are associated with sleep disorders?

researchers reported at the 2007 Scientific Meeting of the American Association forHeartthat lipid-lowering drugs may affect sleep in some patientsThe findings are important because sleep problems can affect quality of life and can lead to poorhealthproblems, such as stimulating weight gain and insulin resistance, said Lead author Andrice Golom, M.D., an assistant professor of family preventive medicine at California State University's San Diego School of MedicineIn the largest study of its kind, researchers compared two statins with statins, lipolateatin (soluble in lipids) and hydrophilic provastatin (soluble in water)Because simvastatin is fat-soluble, it is easier to enter the brain through the cell membrane and through the blood-brain barrierThe brain controls sleep, and many brain nerve cells outsource insulated lipids called myelinThe results showed that patients taking simvastatin had severe reduced sleep quality, and patients taking simvastatin had significantly higher sleep problems than those taking papalstatin or taking a placeboOn average, so, liposuction has a stronger effect on sleep qualityIn past studies and case reports, some patients taking statins reported insomnia or nightmaresGolomb said several small studies have been conducted in the early stages, including studies focusing on the comparison of prolipidate statins with hydrophilic statinsBut perhaps because of the short follow-up time and the fact that only a small number of patients (usually fewer than 20 people - such a small number of patients are not enough to observe this difference), most researchers did not notice the differences that affect sleepOne of the studies did report a significant difference between provastatin and simvastatinHowever, this effect has not been determined because no more and larger studies have been doneFor the study, researchers conducted a six-month randomized double-blind placebo-controlled trial of 1,016
healthy adult men and women, with participants randomly divided into three groups, simvastatin (20 mg), provastatin (40 mg) and a placebo control group The results were then evaluated before and during treatment with the Leeds Sleep Assessment Scale (an intuitive equivalent of sleep quality) and the Sleep Disorders Scale It was found that those who reported that the experimental drug treatment severely damaged sleep also showed significant adverse changes in the attack index compared to other patients Golomb also noted that while the average effect of simvastatin on sleep is harmful, that doesn't mean every patient who takes simvastatin has a worse sleep quality Considering that patients may have been assigned to the placebo group in randomized trials, the researchers did not include patients with heart disease or diabetes Golomb suggests that patients with sivastatin sleep problems should consult a doctor, and that lack of sleep is a big problem for a small number of people The National Institutes of Health's Heart, Lung, and Hematology Institute funded the study