Discussing the "previous life and present life" of jaundyl hydrochloride

Speaking of small alkali, you may be a little strange, but a familiar after-the-post language we must all know: dumb eat yellow even - there is bitter can not say! Yes, the most important ingredient in the bitter taste of jaundium is jaundium, or jaundate.
This is isoquine alkaloid distributed in a variety of natural herbs, which is present in jaundice in the form of hydrochloric acid (small hydrochloride hydrochloride), which has been found to be used in the treatment of tumors, hepatitis, cardiovascular disease, hypertension, inflammation, bacterial and viral infections, diarrhoea, Alzheimer's disease and arthritis.
The source of history" Huang Liansin was first discovered in the pre-Qin period, with the further deepening of pharmacological research, China's Han Dynasty, "Shen Nong Herbs" has recorded the efficacy of Huang Lian in detail, this book is the earliest existing Chinese medicine works, history originated in Shen Nong's, in the East Han Dynasty 25-220 A.D. assembled into a book.
and its monocrystalline structure was first resolved from an extract separated from Hydrastis canadensis in 1917.
"medical use" 01 antioxidant effect Under normal circumstances, the body maintains a balance between antioxidants and oxidants.
and oxidative stress is a harmful process that can be an important medium for damage to cellular structure, leading to disease conditions such as cardiovascular disease, cancer, neurological disease and diabetes.
production of reactive oxygen (ROS), most commonly through cytokine overstulgation of NADPH or through mitochondrial electron transfer chains and jaundice oxidase, can lead to oxidative stress.
experiments showed that the metabolites and chlorophylline showed excellent -OH removal activity, which was roughly equivalent to the powerful antioxidant vitamin C.
given small pyridine in diabetic-molded rats to monitor an increase in SOD (superoxide dismigase) activity and a decrease in MDA (lipid peroxidation marker) levels.
further results show that the removal activity of small pyridine is closely related to the chelation activity of its iron ions, and the C-9 hydroxyl of small pyridine is the necessary part.
02 Anti-tumor effect There have been numerous reports of the anti-cancer effects of lycopane, which has been shown in recent years to be of great significance in the complementary treatment of serious cancer diseases such as ovarian cancer, endometrial cancer, cervical cancer, breast cancer, lung cancer, colorectal cancer, kidney cancer, bladder cancer, prostate cancer, etc.
small pyridine can inhibit the proliferation of tumor cells by interacting with various targets and mechanisms, which can change the expression of cancer genes and genes associated with cancer, in order to regulate the activity of the relevant enzymes to inhibit proliferation.
03 cardiovascular effect lycotine plays an important role in the treatment of cardiovascular disease, and its application is extremely extensive.
small pyridine by reducing the occurrence of cystic premature fights and inhibiting the occurrence of cerial titration, so as to achieve the goal of anti-arrhythmic disorders.
In second, blood lipid abnormalities are the main risk factors for cardiovascular disease, characterized by elevated levels of total cholesterol, triglycerides and LDL, as well as lower levels of high-density lipoprotein (HDL), which can be extremely stable.
long-term hyperlipidemia is an important cause of atherosclerosis plaque formation.
, it has been reported that lysine affects LDL ligen in liver cells to lower serum cholesterol levels in liver cells.
addition to this, calp is positively muscular and has been used to treat congesitive heart failure.
04 Endocrine Effect Diabetes (DM) is a metabolic disorder characterized by elevated blood sugar levels (high blood sugar) caused by the failure of pancreatic B cells to produce enough insulin, or loss of effective target tissue response to insulin.
the sugar-lowering effects of small carbalins were discovered by chance in the 1980s in the treatment of diarrhea patients with diabetes.
Many studies have shown that nicotine lowers blood sugar by inhibiting mitochondrial glucose oxidation and stimulating glycolysis, which then increases glucose metabolism; reducing ATP levels by inhibiting mitochondrial function in the liver; and inhibiting the activity of DPP 4, a common serine protease, to crack certain peptides, which increase insulin levels in the case of high blood sugar.
is beneficial for improving insulin resistance and glucose utilization in tissues by reducing lipids (especially triglycerides) and plasma free fatty acid levels.
"Future development" Although the current chlorinated small pyridine has been widely used in clinical, but one of the disadvantages can not be ignored is that it belongs to the BCS II class of drugs, with poor water solubility, and is not conducive to patient absorption, so how to develop appropriate drugs is an urgent problem to be solved.
Pharmatically commonly used to increase water solubility is usually to add a large number of water-soluble accessories, but the attendant problem is a decrease in dose flexibility and a decrease in patient compliance, so more rational ways are needed to improve the bio-use of the drug.
The usual methods are amorphotic dispersions, medicinal salts and drug cocrystalline, but amorphoation usually still needs to be deformed to maintain its stability, and the applicability of salts is generally applicable to drugs with ionized groups, compared with drug cocrystalline reflects its advantages: simple process, low cost, excellent results.
there are two main types of drug cocrystalline design for hydrochloric acid nicotine, one is to form cocrystalline with acid ligation, and the other is to form cocrystalline with flavonoids.
The former in biological utilization has a greater improvement, but whether the ligation can be used for long-term clinical use is still to be tested, and the cocrystalline design of flavonoids although the bio-utilization is not as good as the former, but cleverly through crystal engineering method to improve the combination of the two small molecule drugs, can jointly improve the efficacy of the two, is a more successful method to improve the physical and chemical properties.
Today, small pyridine can be synthesized and modified by crystal engineering methods, low cost, advanced technology, and with the development of medical research and chemical research in-depth, small pyridine will certainly show more medicinal effects.
On the one hand, the design and morphological analysis of microcosmic engineering have not only achieved remarkable results in the field of antibacterial, antiviral, anti-inflammatory, anti-tumor, anti-diabetic, and treatment of cardiovascular diseases in traditional pharmacological research.
because of its remarkable efficacy and small toxic side effects, it has great potential for clinical application and has broad prospects.
with the development of cell biology, the pharmacological mechanism of nicotine will be clarified from the cell level and even the molecular and target levels, providing more theoretical basis for its clinical application.
: 1.Li Z, Geng Y N, Jiang J D, et al. Antioxidant and anti-inflammatory activities of berberine in the treatment of diabetes mellitus[J]. Evidence-Based Complementary and Alternative Medicine, 2014, 2014. 2.Hou Q, Tang X, Liu H, et al. Berberine induces cell death in human hepatoma cells in vitro by downregulating CD147[J]. Cancer science, 2011, 102(7): 1287-1292. 3.Tillhon M, Ortiz L M G, Lombardi P, et al. Berberine: new perspectives for old remedies[J]. Biochemical pharmacology, 2012, 84(10): 1260-1267. 4.Marin‐Neto J A, Maciel B C, Secches A L, et al. Cardiovascular effects of berberine in patients with severe congestive heart failure[J]. Clinical cardiology, 1988, 11(4): 253-260. 5.Chen F L, Yang Z H, Liu Y, et al. Berberine inhibits the expression of TNFα, MCP-1, and IL-6 in AcLDL-stimulated macrophages through PPARγ pathway[J]. Endocrine, 2008, 33(3): 331-337. 6.Li P, Ramaiah T, Zhang M, et al. Two Cocrystals of Berberine Chloride with Myricetin and Dihydromyricetin: Crystal Structures, Characterization, and Antitumor Activities[J]. Crystal Growth & Design, 2019, 20(1): 157-166.