Discover genetic fundamentals, major breakthrough in research on motor neurone disease

, scientists at King's College uk have announced a major breakthrough in the study ofmotorneuronaldisease, discovering the genetic basis of thedisease, an important milestone in understandingmotorneurone diseaseThe study was published in the recent lysis of the American journal ScienceMotor neurons are nerve cells that control the movement of human musclesMotor neurons located in the brain are called upper motor neurons, and motor neurons located in the brain stem and spinal cord are called hypomotor neuronsWhen motor neurons become lesions, the muscles are unable to function properly because they do not receive instructions from the brain and spinal cordSuffering from the disease is very terrible, patients almost day by day to watch their muscles become weak and atrophy, watching their lives day by day to dieThere are currently about 5,000 patients in the UK and about five people die from the disease every dayThe disease develops so fast that almost all muscles in the body are affected within two to five yearsHawking, a famous scientist who has suffered from the disease, has been fighting it for nearly 35 years Motor neurone disease has its own recorded for more than 100 years, the cause of which is still unknown Explanations including immunodisorders, toxins, viruses and geneticthesis have been put forward, but only some of these phenomena have been explained As the mechanism of disease-causing mechanism cannot be determined, there are no cures so far The team, led by Professor Chris Shaw of King's College London, found that a mutation in a gene called TDP-43 may be linked to the disease Although only 5% to 10% of cases of motor neurone disease are familial, scientists found clusters of TDP-43 proteins in motor neuroncells in 95% of patients, suggesting that the protein has broad implications for causing the disease While caution is over the prospects for curing the disease, scientists believe the discovery will help unravel the complex and mysterious mysteries of motor neurone disease and help scientists build animal models to test new therapeutic drugs and new treatments (He Yi)