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▎WuXi AppTec content team editor
glioblastoma multiforme glioblastoma (GBM) is a common glioma, its degree of malignancy is very high, and the existing treatment methods have very limited efficacy on GBM.
The median survival is only 15-18 months, and the five-year survival rate after diagnosis is even less than 7%.
Patients with GBM often have difficulty avoiding relapse after treatment, which is a key reason for
the poor prognosis.
To this end, scientists have tried many ways to control GBM as well as other brain tumors
.
One potential treatment is cryocryocryo, which was first proposed in the 40s, where researchers have found that cryocryopreservation works well for removing brain tumors, but is shelved
because it inevitably causes damage to healthy tissue.
Recently, researchers at Emory University and the University of Texas in the United States tried this method again, but they have innovated in the past, according to the research team's paper published in Science Advances, this new method is called cell homeostatic cryogenics, which is mainly operated by a special cryogenic device.
It continuously cools the local brain without damaging surrounding tissues
.
The device consists of an array of probes, cold plates, and water pipes, part of which is placed in a specific area of the brain to absorb heat and then pass it to an outer cooling plate, while the water circulates and carries the heat away
when it touches the cold plate.
After transplanting the device into the brains of GBM rats, the rats were still able to walk and eat
normally.
When the device is turned on, the temperature of the tumor area of the mouse can drop significantly, and compared with the normal body temperature, the new device can control the tumor temperature to 20-25 °C, which is enough to reach the temperature threshold
of tumor growth inhibition.
▲ The study envisaged a concept of a cryogenic device installed in the human body (Image source: Reference [1])
Throughout the experiment, rats carrying the device successfully survived, and their survival time was about twice as long
.
"Since the right temperature is necessary for numerous biochemical and cellular responses, other tumor types may also benefit
.
" Study author Dr.
Syed Faaiz Enam noted
.
However, the researchers pointed out that this low-temperature method does not kill cancer cells, but only inhibits
its growth.
But this physical approach not only significantly reduces the side effects of drugs, but also prevents cancer cells from evolving, buying time
to try different anti-cancer therapies.
The researchers are planning to advance clinical trials
of the device in human volunteers.
References: [1] Syed Faaiz Enam et al, Cytostatic hypothermia and its impact on glioblastoma and survival, Science Advances (2022).
DOI: 10.
1126/sciadv.
abq4882[2] Cooling glioblastoma to room temperature extends survival in preclinical study.
Retrieved December 16, 2022 from https://medicalxpress.
com/news/2022-12-cooling-glioblastoma-room-temperature-survival.
html
glioblastoma multiforme glioblastoma (GBM) is a common glioma, its degree of malignancy is very high, and the existing treatment methods have very limited efficacy on GBM.
The median survival is only 15-18 months, and the five-year survival rate after diagnosis is even less than 7%.
Patients with GBM often have difficulty avoiding relapse after treatment, which is a key reason for
the poor prognosis.
To this end, scientists have tried many ways to control GBM as well as other brain tumors
.
One potential treatment is cryocryocryo, which was first proposed in the 40s, where researchers have found that cryocryopreservation works well for removing brain tumors, but is shelved
because it inevitably causes damage to healthy tissue.
Recently, researchers at Emory University and the University of Texas in the United States tried this method again, but they have innovated in the past, according to the research team's paper published in Science Advances, this new method is called cell homeostatic cryogenics, which is mainly operated by a special cryogenic device.
It continuously cools the local brain without damaging surrounding tissues
.
The device consists of an array of probes, cold plates, and water pipes, part of which is placed in a specific area of the brain to absorb heat and then pass it to an outer cooling plate, while the water circulates and carries the heat away
when it touches the cold plate.
After transplanting the device into the brains of GBM rats, the rats were still able to walk and eat
normally.
When the device is turned on, the temperature of the tumor area of the mouse can drop significantly, and compared with the normal body temperature, the new device can control the tumor temperature to 20-25 °C, which is enough to reach the temperature threshold
of tumor growth inhibition.
▲ The study envisaged a concept of a cryogenic device installed in the human body (Image source: Reference [1])
Throughout the experiment, rats carrying the device successfully survived, and their survival time was about twice as long
.
"Since the right temperature is necessary for numerous biochemical and cellular responses, other tumor types may also benefit
.
" Study author Dr.
Syed Faaiz Enam noted
.
However, the researchers pointed out that this low-temperature method does not kill cancer cells, but only inhibits
its growth.
But this physical approach not only significantly reduces the side effects of drugs, but also prevents cancer cells from evolving, buying time
to try different anti-cancer therapies.
The researchers are planning to advance clinical trials
of the device in human volunteers.
References: [1] Syed Faaiz Enam et al, Cytostatic hypothermia and its impact on glioblastoma and survival, Science Advances (2022).
DOI: 10.
1126/sciadv.
abq4882[2] Cooling glioblastoma to room temperature extends survival in preclinical study.
Retrieved December 16, 2022 from https://medicalxpress.
com/news/2022-12-cooling-glioblastoma-room-temperature-survival.
html
