Differences in immune responses are a key factor leading to the prognosis difference seigniort sourcing of COVID-19 men and women!

, June 30, 2020 /
PRNewswire/ -- Data from global CASES of COVID-19 show that men are more likely to be infected with the new coronavirus than womenDifferences in the immune response to the virus between men and women may help explain this phenomenona new study suggests that when infected with a new coronavirus, women may have a stronger, more adaptive immune response than menIn contrast, men's immune response appears to have progressed more slowly, leading to inflammation that is harmful to the bodythe study is the first to study the gender differences in how the immune system protects the body from the SARS-CoV-2 virusAkiko Iwasaki, a researcher at the Howard Hughes Institute of Medicine, says this helps explain why men suffer from more serious diseasesShe and her colleagues published a pre-print edify of the study on MedRxiv.org on June 9, 2020Their analysis focused on the immune response of 93 patients admitted to The University of New Haven"Women respond to the virus that causes COVID-19 very differently from men," said Iwasaki, an immunologist at the National Institute of Allergy and The Diseases, NIHThe gender differences revealed in the study suggest that treatment options can be tailored to the differences between male and female patientsMarcus Altfeld, aofimmunology at the Heinrich Pett Institute in Germany,who was not involved in the study, said medRxiv's paper had not gone through what is known as a peer-reviewed scientific review process and had some limitations, including reliance on a small number of patientsHowever, he added, "these are very important data, and more follow-up research is needed now." "
a new gender gap
since the emergence of SARS-CoV-2, researchers have shown that the virus is almost indiscriminate It poses a greater threat to certain categories of people, including the elderly, people with certain diseases, and African-Americans Early reports suggested that male infections were more severe, a trend that was later confirmed elsewhere in the world the extent of this gap between men and women varies Data from the U.S Centers for Disease Control and Prevention as of early June showed that men accounted for 54 percent of COVID-19-related deaths Meanwhile, an analysis of data on more than 1,000 Chinese people found that men died 2.4 times more than women experts have identified a long list of possible reasons for this difference, including male sex hormones, men's lack of attention to their own health, and a molecular level required for viruses to invade cells immune system has become a strong candidate "In many viral infections, there are differences in the performance of the disease and the development of immune response, which has been well documented," said Altfeld, who studies HIV , encouraged by the Yale Center for Women's Health Research, Iwasaki set out to study the role of male and female immune differences in COVID-19 Using blood, saliva and nasal swabs taken from hospital patients, she and her team focused on men and women with moderate disease immune response is divided into two parts
Iwasaki's team found differences from the immune system's two layers of defense When the infection begins, the first layer reacts quickly Infected cells alert, emit cytokine proteins, and summon immune cells to fight infection This process is called inflammation and, while necessary, can be dangerous if left unchecked In COVID-19, uncontrolled inflammation known as cytokine storms can lead to death within a few days, the second layer of defense of the immune system began to work This delicate response attracts so-called T-cells and B-cells, which learn to identify and destroy enemies Photo Source: medRxiv
research team found that female patients had more antiviral T cells, while male patients had higher levels of inflammatory cytokines "This suggests that men are trapped in the first layer of the immune response," Isaki said She explains that because men don't activate the second, more targeted defense system properly, inflammation increases her team also tracked the severity of the patient's condition Men with stable physical condition shave strong T-cell reactions, no different from women However, men who lack a strong T-cell response are worse off - they need to move to an intensive care unit or breathe on a ventilator Some women struggle, too, but for different reasons: they fail to control cytokine signals overall, the results showed that women performed better than men because of the presence of T cells Although men's T-cell levels decline dearly with age, women's T-cell levels remain strong in their 90s She said the findings suggest that male patients may benefit from the treatment of t-cell enhancement (BioValleyBioon.com) References: Takehiro Takahashi et al.
Sex differences in immune responses to SARS-CoV-2 that underlyi disease outcomes , (2020) DOI: 10.1101/2020.06.06.20123414 W
hymen may fare worse than women against SARS-CoV-2 .