Diabetes, Obesity and Metabolism: Data from 500,000 people suggest that cognitive impairment may begin in prediabetes

At present, the scientific community agrees that people with diabetes have a wide range of cognitive impairments, such as memory loss, distraction, and decreased execution.
sea mass is closely related to cognitive function.
is the center of learning, memory, and directional nerves.
found that at high blood sugar, the production of reactive oxygen drinking free agents, glucose toxicity to neurons led to damage to the sea horse.
although there is much evidence that diabetes can cause neurodegenerative lesions, the effects of blood sugar on the brain remain unclear throughout the blood sugar spectrum.
especially in low hyperglycemia states.
a recent study published in the journal Diabtes, Obesity and Metabolism found that people with higher-than-normal blood sugar levels were 42 percent more likely to have cognitive decline and an average 54 percent higher risk of developing vascular dementia.
the study, researchers asked 500,000 participants aged 40-69 from the UK Biobank database how different blood sugar levels or blood sugar states affect cognitive function.
the participants were tested with HbA1c, which determined average blood sugar levels over the past 2 to 3 months, and were divided into five groups based on the results: known diabetes, undiagnosed diabetes, and prediabetes (HbA1c in 4 2 to 48 mmol/mol), normal blood sugar (HbA1c at 35 to 42 mmol/mol) and hypoglycemia (HbA1c at .lt;35 mmol/mol).
results showed that participants were repeatedly assessed for visual memory data to determine whether they had cognitive decline.
the absolute rate of cognitive decline was low, pre-diabetics and diabetics were similarly likely to have cognitive decline, at 42 percent and 39 percent, respectively.
the relationship between blood sugar and cognitive function in the diagnosis of dementia, the researchers found that pre-diabetes and vascular dementia are more likely.
, diabetics are three times more likely to develop vascular dementia than normal blood sugar levels, and at higher risk of Alzheimer's disease.
, undiagnosed diabetes, prediabetes, and known diabetics have higher and smaller sea mass (WMH) in the brain whiteness.
those taking antihypypants may have more WMH and smaller sea mass.
, both pre-diabetes and known diabetes were significantly associated with vascular dementia, cognitive decline, AD risk, and decreased sea mass volume.
pre-diabetes can reduce the risk of type 2 diabetes by eating a healthy diet, eating a balanced diet, exercise more and maintaining a healthy weight.