Diabetes Care: Weight loss depends on your brain!

Obesity and type 2 diabetes (T2DM) are one of the biggest global health challenges of our time
.

Health systems around the world are investing heavily in population-based weight loss strategies, and the debate over the most effective way to achieve long-term health improvement continues

Obesity and type 2 diabetes (T2DM) are one of the biggest global health challenges of our time

Currently, only bariatric surgery are shown to produce lasting weight loss, and into long-term remission and improve diabetes and even heart blood vessels to reduce and cancer-related mortality
.

The mechanism of the metabolic benefits of bariatric surgery is still not fully understood

Currently, only bariatric surgery are shown to produce lasting weight loss, and into long-term remission and improve diabetes and even heart blood vessels to reduce and cancer-related mortality

The shortcomings of the above-mentioned studies highlight the need for a study to match and compare groups of diabetic patients who have improved blood sugar through different interventions
.

In order to solve these important clinical problems, experts from Imperial College of the United Kingdom carried out related research, using fMRI to compare the two groups with diabetes before and after achieving weight loss through Roux-en-Y gastric bypass (RYGB) or VLCD.

Correlation of brain regions with DEBQ and weight loss and resting state data

The study included 16 participants who underwent gastric bypass surgery, and 19 matched participants underwent 4 weeks of VLCD (meal replacement)
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Before and after the intervention, head fMRI was used to evaluate the brain's response to food cues and the functional connection of the resting state, and the comparison between each group was made

The results show that, compared with VLCD-induced weight loss, Roux-en-Y gastric bypass surgery causes three different brain responses: 1) VLCD leads to increased brain reward center food cues responsiveness, while in RYGB, this response is reduced; 2) VLCD leads to higher neural activation of food cues in the cognitive control area, which is related to the exercise of more cognitive restraint on diet, which RYGB does not; 3) After RYGB-induced weight loss, it balances the appetite system (hypothalamic As the center) to participate better than VLCD
.

Compared with VLCD-induced weight loss, Roux-en-Y gastric bypass surgery leads to three different brain responses: 1) VLCD leads to increased brain reward center food cues responsiveness, while in RYGB, this response is reduced; 2) VLCD It leads to higher neural activation of food cues in the cognitive control area, which is related to the exercise of more cognitive restraint on diet, which RYGB does not; 3) After RYGB-induced weight loss, balance the appetite system (the hypothalamus is the center) Participate better than VLCD
.

Compared with VLCD-induced weight loss, Roux-en-Y gastric bypass surgery leads to three different brain responses: 1) VLCD leads to increased brain reward center food cues responsiveness, while in RYGB, this response is reduced; 2) VLCD It leads to higher neural activation of food cues in the cognitive control area, which is related to the exercise of more cognitive restraint on diet, which RYGB does not; 3) After RYGB-induced weight loss, balance the appetite system (the hypothalamus is the center) Participate better than VLCD

Functional ROI analysis of food tasks

Taken together, these findings indicate that in diabetic patients, the brain responds differently to different weight loss methods, which may explain the weight recovery after short-term VLCD, in contrast to the lasting weight loss after RYGB
.

Taken together, these findings indicate that in diabetic patients, the brain responds differently to different weight loss methods, which may explain the weight recovery after short-term VLCD, in contrast to the lasting weight loss after RYGB
.

Taken together, these findings indicate that in diabetic patients, the brain responds differently to different weight loss methods, which may explain the weight recovery after short-term VLCD, in contrast to the lasting weight loss after RYGB

references:

Weight Loss by Low-Calorie Diet Versus Gastric Bypass Surgery in People With Diabetes Results in Divergent Brain Activation Patterns: A Functional MRI Study.

Weight Loss by Low-Calorie Diet Versus Gastric Bypass Surgery in People With Diabetes Results in Divergent Brain Activation Patterns: A Functional MRI Study.
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