Diabetes care: lilalutide enhances the decrease of prediabetes

The proportion of individuals who lost 5%, 7% and 10% of their body weight in different treatments
In order to evaluate the effect of lilalutide on weight loss, insulin resistance, risk factors of CVD and inflammation in high-risk population of type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD), a study was conducted by Dr Kim et al From the Department of internal medicine, Stanford University School of medicine, California It was found that in high-risk population of T2DM and CVD, while limiting calorie intake, lilalutide was added Laglutide significantly increased weight loss, improved insulin resistance, systolic blood pressure, blood glucose and triglyceride concentration The results were published online in the July 8, 2013, American Journal diabetes care   In this study, 68 overweight / obese elderly individuals (average age 58 ± 8 years) with prediabetes were randomly assigned to receive 1.8mg of lilalutide and placebo for 14 weeks All subjects reduced their calorie intake by 500 calories per day During the insulin inhibition test, the peripheral insulin resistance was quantified by measuring the steady-state blood glucose (SSPG) concentration, and the traditional CVD risk factors and inflammatory markers were also evaluated   The results showed that 11 of the 35 subjects in the lilalutide group (31%) terminated the study, while 6 of the 33 subjects in the placebo group (18%) terminated the study (P = 0.26) Subjects who continued to use lilalutide (n = 24) lost twice as much weight as those in the placebo group (n = 27) (P < 0.001) The concentration of SSPG was also significantly improved (P < 0.001), while the decrease of systolic blood pressure, fasting blood glucose and triglyceride was significantly increased (P < 0.04) There was no difference in inflammatory markers between the two groups, but the pulse increased after treatment with rilalutide (P = 0.001)   It was found that in T2DM and CVD high-risk groups, the addition of rilalutide significantly increased the weight loss effect, improved insulin resistance, systolic blood pressure, blood glucose and triglyceride concentration while limiting the calorie intake.