Deep understanding of how scientists are looking for new links to cancer metabolism!

, June 28, 2020 /
BiovalleyBIOON/ -- Imagine that there is now a row of dominoes, and when one is knocked down, the rest will roll down, and so will the cancer, and when a cell starts to cancer, the important cellular pathways are altered, like a chain reaction, when a point in the pathway is sudden, downstream is affected like a dominoSome of the pathways that are destroyed in cancer regulate the way cells acquire or process energy, i.ethe metabolism of cellsWhile researchers have learned a lot about the errors that disrupt metabolic pathways in cancer, there has been little research on how these mutations are linked to the mechanisms of cellular behavior; researcher DrGeorge Poulogiannis, who is responsible for studying the link between cell metabolism, cancer and diet, says that by looking for new associations in cancer metabolism or by helping researchers better understand the pathogenesis of cancer and developing new, more targeted therapiesTo solve such a complex puzzle, researchers need a rather unique toolpicture source:, Phospho Biomedical AnimationTo assess metabolic changes in cancer cells, researchers developed a tool called iKnife, an electric surgical device that sniffs out cancer during surgery and has been tested inbreastand ovarian cancer, explains researcher Poulogiannis, who a few years ago introduced a very simple-thinking technique that connects electronic surgical devices to mass spectrometers and determines the ionization of smoke being producedusing this technique, iKnife is able to accurately distinguish between cancer and non-cancer tissue in real time, meaning surgeons can know if they cut healthy tissue or cancer in just seconds after the first cut, and researchers want to delve into it to prove whether the technology can gather more detailed information on cancer biology and key drivers of disease;looking for clues
researcher Poulonnis says they're ready to dig deeper in the fieldLooking for patterns that could explain metabolic and cancer cues, and they screened some breast cancer cell lines,tumor samples and mouse models; the results showed that breast cancer samples could be divided into two distinct categories based on the presence of specific fats sniffed by the iKnife tool, which did not appear to be associated with any of the characteristics currently used by clinicians to group the disease Such as hormone receptor status The researchers further found that differences in fat performance could be explained by mutations in key genes that are key components in the PIK3CA metabolic pathway one of the high levels of fatty acids found in the sample is peanut tetraoleic acid, a fatty acid found mainly in animal fats found on a daily diet, and which is also produced by cancer cells; The researchers tried to find the molecular mechanisms hidden behind, and they found that some signaling pathways downstream of the carcinogenic PIK3CA regulate the excessive production of lipids, while the biomarkers fatty acids that attracted the researchers' attention are peanut tetraoleic acid, because they can act as the main hub for inflammatory reactions in cancer, which we can obtain from the diet, and that piK3CA mutant cancer cells have a special ability to increase the production of tetraoleic acid now researchers are using the iKnife tool to start slowly collecting fragments, like a domino arranged together, creating a previously uncommon connection between mice that may have been the right to interfere with the PIK3CA signaling pathway when they were fed a fatty acid-free diet Slowing down the growth of tumor in mouse organisms is more effective; scientists have previously known that errors in the PIK3CA pathway may be a sign of a lack of response to a particular inhibitor, but no one understands why, and now, with the help of iKnife tools, researchers have found that the loss of reactions may have been caused by an excess of peanut tetraoleic acid complete picture
researcher Poulogiannis and colleagues began to follow clues along the PIK3CA pathway to parse the link between diet, metabolism and cancer, perhaps one of the first, and perhaps the first to reveal a key role in dietary fat restriction in therapeutic responses Although the study is still early, researchers are excited that these techniques are changing the way we find new links in cancer metabolism and guide the potential for future treatment of cancer; in this study, researchers have successfully used high-throughput technology to reveal how metabolic phenotypes can really help explain biological mechanisms, and ultimately identify a new type of metabolic susceptibility, as well as a new way to target tumor (BioValleyBioon.com) References: 1
Searching for Novels in Cancer
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Stitching a', 'Google Earth' for Cancer .