Daqing Oilfield General Hospital confirms increased iNOS activity reflects BCC development

nitric oxide as an important messenger molecule in living organisms, when its activity increases, it can reflect the proliferation of base cell carcinoma (BCC) and the aggressive behavior oftumorcells, while bCC proliferation andtumorthe invasive behavior of cells, can promote BCC The occurrence and development of the generalhospital in Daqing Oilfield, Heilongjiang Province,, deputy director of the department of dermatology Zhang Xinping, in his recently completed "nitric oxide enzyme (NOS) expression and immunonic grouping in the base cell carcination" the subject, at home and abroad for the first time to reach this important conclusionAs one of theof malignant skintumors in clinical clinic, the incidence of BCC has been on the rise in recent yearsBCC has multiple and recurrent characteristics in clinical and histology, locally destructive, less regional lymph node metastasis, and remote metastasis is rareSome scholars have explained the mechanism of BCC from the perspective of mutation inactivation of anti-cancer gene and protein-mediated apoptosis, but there are no studies on the relationship between BCC and nitric oxide asseZhang Xinping used immunohistocitization to detect the pathology specimens of 40 BCC patients for the first timeThe results show that iNOS (induced nitric oxide enzyme) can be activated by inflammatory cells and tumor cells, while the increase of iNOS activity can reflect the proliferation of tumor cells and aggressive behavior of tumor cells, while bCC proliferation and aggressive tumor cells can promote the development of BCCClinically, BCC is also known as aggressive ulcers, which are prone to bleedingThe experiment found that above the blumps of BCC, i.eclose to the pale layer of the dermis, visible significantd dilating blood vessels, and large tube cavity, and in tumor block interstitial blood vessel dilation is not significant, even rare, making BCC slow growth and rare metastasis, so it does not support iNOS in the substrate cell cancer to promote tumor vascular formation mechanism The study also found that eNOS (endothelial structural nitric oxide enzyme) in pathological conditions, can increase tumor vascular permeability, promote tumor growth and metastasis, in BCC showed low expression This finding further supports the biological characteristics of BCC growth and rare metastasis, while the increase in iNOS activity reflects the proliferation and invasive behavior of tumor cells, such as local izedogenous ulcers, especially in the eyelids, nasal wings, etc., if the treatment is not timely can invade the eye conjunctiva and nasal cavity, speeding up the development process of BCC Expert evaluation points out that the above-mentioned research deeply explores the intrinsic relationship between the pathogenesis of BCC and its special biological effects from the molecular biology approach, which not only helps to deepen the understanding of bCC occurrence and development, but also provides a scientific basis for exploring the new method of treatment of the disease (Yi Xiaofeng; Li Huaxuan)