Dangerous brain cells help cancer invade
-
Last Update: 2020-12-28
-
Source: Internet
-
Author: User
Search more information of high quality chemicals, good prices and reliable suppliers, visit
www.echemi.com
cells from various tumors invade the brain with the help of an unexpected helper, a star cell that is itself part of the brain.
cancer cell metastasis refers to organs that spread from their original positions in the body to distant locations. This results in 80% of cancer deaths, but there are few treatments for metastatic brain cancer. Metastatic brain cancer is "seeded" by melanoma, breast cancer and other cancer cells.
Qing Chen of the Westa Institute in Philadelphia, Pennsylvania, and colleagues found that a brain cell called astrology glial cells promotes the proliferation of cancer cells that have penetrated the brain. The researchers showed that astroid glial cells transfer brain fatty acids to invading cancer cells. Fat and PPAR-γ proteins in metastatic cells trigger a molecular path, leading to cell proliferation.
researchers injected mice with cancer with a compound that blocks PPL-γ cancer. Subsequently, their brain tumors stopped growing.
study, published recently in Cancer Discovery, the authors say this suggests that compounds that block PPAR-γ can help control brain cancer metastasis. They speculate that the role of PPAR-γ may depend on the type of cancer. As a result, treatments for it may be more helpful for some of these cancer patients. (Source: Jin Nan, China Science Journal)
related paper information:
This article is an English version of an article which is originally in the Chinese language on echemi.com and is provided for information purposes only.
This website makes no representation or warranty of any kind, either expressed or implied, as to the accuracy, completeness ownership or reliability of
the article or any translations thereof. If you have any concerns or complaints relating to the article, please send an email, providing a detailed
description of the concern or complaint, to
service@echemi.com. A staff member will contact you within 5 working days. Once verified, infringing content
will be removed immediately.
