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Cryo-electron microscopy structure of human brain amyloid β42 filaments

 Last Update: 2022-01-22
 Source: Internet
 Author: User

High-resolution observation of human Aβ42 fibrils

Alzheimer's disease is characterized by loss of memory and other cognitive functions and the filamentous assembly of Aβ and tau in the brain

Assembly of Aβ peptides into filaments ending at residue 42 is a central event

Here, we report the cryo-electron microscopy (cryo-EM) structure of Aβ42 filaments from human brain

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