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Despite growing interest in therapeutic strategies to limit oxygen in ICU patients, no studies have compared conservative and standard oxygen in postoperative patients with sepsis/septic shock, although there are indications that it May improve patient outcomes
.
Studies have shown that high partial pressure of oxygen (PaO2) in arterial blood can reduce the rate of surgical wound infection and mortality in major surgery patients
Infect
Recently, a research article was published in Critical Care, an authoritative journal in the field of critical care medicine.
The study aimed to evaluate whether PaO2 is associated with the risk of death after major surgery in adult sepsis/septic shock patients
.
The researchers conducted a secondary analysis of a prospective observational study that included 454 patients who underwent major surgery and were admitted to the ICU
.
Patients were divided into two groups according to the presence or absence of hyperoxemia on the day of the sepsis/septic shock attack
diagnosis
Among patients with PaO2 ≤ 100 mmHg, we found prolonged mechanical ventilation (2[8] vs 1[4] days, p<0.
001) and longer ICU stay (8[13] vs 5[9] days, p <0.
001), higher severity of organ dysfunction assessed by SOFA score (9[3] vs 7[5], p<0.
001), and higher prevalence of septic shock (200/238, 84.
0% vs 145 /216) 67.
1%, p<0.
001) and higher 90-day mortality (37.
0%[88] vs 25.
5%[55], p=0.
008)
.
In multivariate analysis, hyperoxemia was associated with higher 90-day survival (OR 0.
CONCLUSIONS: PaO2 higher than 100 mmHg was associated with 90-day mortality, ICU stay and intubation time in patients with severe postoperative sepsis/septic shock
.
.
Original source:
Original source:Marta Martín-Fernández, et al.
Hyperoxemia in postsurgical sepsis/septic shock patients is associated with reduced mortality
