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Corning Jereh KN046 combined with chemotherapy in the treatment of advanced pancreatic cancer phase III clinical application approved by CDE

 Last Update: 2022-02-26
 Source: Internet
 Author: User

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On November 24, the Phase III registration clinical study (KN046-303) of Corning & Jereh’s PD-L1/CTLA-4 bispecific antibody KN046 combined with nab-paclitaxel and gemcitabine in the treatment of advanced pancreatic cancer was approved by the State Drug Administration.

KN046-303 is a multicenter, randomized, double-blind, phase III clinical study in patients with unresectable locally advanced or metastatic pancreatic cancer without systemic therapy.

Pancreatic cancer is one of the common malignant tumors of the digestive tract with a high mortality rate.

Albumin paclitaxel combined with gemcitabine (AG regimen) is the standard first-line treatment regimen for locally advanced unresectable or metastatic pancreatic ductal adenocarcinoma, but the ORR of this regimen is less than 25%, and it progresses rapidly, so there is a huge clinical need

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